Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG)
Φόρτωση...
Ημερομηνία
Συγγραφείς
Adlercreutz, H.
Hockerstedt, K.
Bannwart, C.
Bloigu, S.
Hamalainen, E.
Fotsis, T.
Ollus, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Steroid Biochem
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
A brief account of our present knowledge on the enterohepatic metabolism of estrogens and on the origin, metabolism and biological effects of mammalian lignans and phytoestrogens is undertaken. Furthermore, recently published results on the effects of dietary fiber, fat and carbohydrates on estrogen metabolism are reviewed. New preliminary results are presented on quantitative assays of lignans and phytoestrogens in urine of women belonging to various dietary and population groups and in a group of chimpanzees. The highest values of lignans and phytoestrogens were found in the non-human primates, and in macrobiotic, lactovegetarian and Japanese women, all groups considered having a low risk for the development of breast and other hormone-dependent cancer. New results on correlations between intake of various fibers, lignan and phytoestrogen excretion and plasma levels of estrogens, free testosterone and SHBG in women are presented. There is a significant positive correlation between the intake of fiber and urinary excretion of lignans and phytoestrogens, and the concentration of plasma SHBG. Fiber intake and urinary excretion of lignans and equol correlated negatively with plasma percentage free estradiol. Enterolactone excretion correlated negatively with plasma free testosterone. It is concluded that dietary macro- and micronutrients seem to play an important role in estrogen metabolism.
Περιγραφή
Λέξεις-κλειδιά
Animals, Bile/metabolism, Breast Neoplasms/metabolism, *Diet, Dietary Carbohydrates/pharmacology, Dietary Fats/pharmacology, Dietary Fiber/pharmacology, Dietary Proteins/pharmacology, Enterohepatic Circulation/drug effects, Estrogens/*metabolism/*pharmacology, *Estrogens, Non-Steroidal, Humans, Intestines/metabolism, *Isoflavones, Lignans, Liver/drug effects/*metabolism, Phytoestrogens, Plant Extracts/metabolism/*pharmacology, Plant Preparations, Sex Hormone-Binding Globulin/*metabolism
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/2826899
http://ac.els-cdn.com/0022473187902007/1-s2.0-0022473187902007-main.pdf?_tid=a487ab23b4e76d0cb8b4d2f9a102f9f9&acdnat=1332750808_e14e293a65daa12d53b7c6e6428a8046
http://ac.els-cdn.com/0022473187902007/1-s2.0-0022473187902007-main.pdf?_tid=a487ab23b4e76d0cb8b4d2f9a102f9f9&acdnat=1332750808_e14e293a65daa12d53b7c6e6428a8046
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής