Bilateral effect of unilateral vasectomy on testicular testosterone biosynthesis

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dc.contributor.authorAntypas, S.en
dc.contributor.authorSofikitis, N.en
dc.contributor.authorRodriguez, F.en
dc.contributor.authorZavos, P. M.en
dc.contributor.authorMiyagawa, I.en
dc.date.accessioned2015-11-24T19:33:03Z
dc.date.available2015-11-24T19:33:03Z
dc.identifier.issn0022-3468-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23490
dc.rightsDefault Licence-
dc.subjectAndrogen-Binding Protein/secretionen
dc.subjectAnimalsen
dc.subjectAutoantibodies/analysisen
dc.subjectChorionic Gonadotropin/pharmacologyen
dc.subjectDogsen
dc.subjectFollicle Stimulating Hormone/blooden
dc.subjectLeydig Cells/metabolismen
dc.subjectLuteinizing Hormone/blooden
dc.subjectMaleen
dc.subjectOrgan Sizeen
dc.subjectSertoli Cells/metabolismen
dc.subjectSperm Counten
dc.subjectSperm Motilityen
dc.subjectSpermatozoa/immunologyen
dc.subjectTestis/anatomy & histology/*metabolismen
dc.subjectTestosterone/*biosynthesisen
dc.subject*Vasectomyen
dc.titleBilateral effect of unilateral vasectomy on testicular testosterone biosynthesisen
heal.abstractTwelve immature male dogs underwent a left vasectomy (group A). An additional five underwent a sham operation (group B). Sixteen weeks after the surgery, the bilateral mean values for caudal epididymal sperm content, the percentage of motile spermatozoa, intratesticular testosterone concentration, and testicular secretion of androgen-binding protein (in vitro) were significantly lower in group A. The mean peripheral serum testosterone responses 3 hours after human chorionic gonadotropin stimulation (3,000 IU) were significantly lower in group A than in group B (6.3 ng/mL v 9.5 ng/mL). These findings indicate a bilateral deficiency in both Leydig and Sertoli cell secretory function in unilaterally vasectomized dogs, resulting in impaired bilateral spermatogenesis and sperm maturation. The authors suggest that unilateral injuries of the vas deferens during hernia operations in children may result in bilateral testicular dysfunction.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8078031-
heal.journalNameJ Pediatr Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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