Baseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis C

Απλή σελίδα τεκμηρίου
dc.contributor.authorEconomou, M.en
dc.contributor.authorMilionis, H.en
dc.contributor.authorFilis, S.en
dc.contributor.authorBaltayiannis, G.en
dc.contributor.authorChristou, L.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorTsianos, E.en
dc.date.accessioned2015-11-24T19:33:32Z
dc.date.available2015-11-24T19:33:32Z
dc.identifier.issn1440-1746-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23544
dc.rightsDefault Licence-
dc.subjectAntiviral Agents/*therapeutic useen
dc.subjectApolipoproteins B/*blooden
dc.subjectCholesterol/*blooden
dc.subjectCholesterol, LDL/*blooden
dc.subjectFemaleen
dc.subjectHepatitis C, Chronic/*blood/*drug therapyen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPredictive Value of Testsen
dc.subjectRetrospective Studiesen
dc.titleBaseline cholesterol is associated with the response to antiviral therapy in chronic hepatitis Cen
heal.abstractBACKGROUND: Hepatitis C virus (HCV) partially interacts with low-density lipoprotein (LDL) receptors, suggesting a role for lipids in regulating HCV clearance. Our aim was to study if baseline lipids can discriminate responders from non-responders among patients with HCV infection. METHODS: A total of 109 HCV patients were studied. Laboratory measurements included serum lipids, aminotransferases and viral load, as well as HCV genotype determinations. RESULTS: Responders (n = 53) had significantly higher serum baseline levels of total cholesterol, LDL cholesterol and apolipoprotein B compared to non-responders (n = 56). Multivariate logistic regression analysis showed that a 10 mg/dL increase in total cholesterol was associated with 3.02 higher odds of responding to treatment (95% CI 1.74-5.32, P < 0.001), while a 10 mg/dL increase in apolipoprotein B levels was associated with 1.81 higher odds of responding to treatment (95% CI 1.37-2.54, P < 0.001), after adjustment for age, sex, body mass index (BMI), smoking habits, baseline viral load, liver histology and administration of pegylated interferon. An inverse association between BMI and response to treatment was also evident (adjusted odds ratio 0.73, 95% CI 0.55-0.96; P = 0.03). CONCLUSION: Baseline serum total cholesterol levels and BMI could be helpful in discriminating responders to antiviral therapy among patients with HCV infection.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1440-1746.2007.04911.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17498221-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2007.04911.x/asset/j.1440-1746.2007.04911.x.pdf?v=1&t=h0p11ldo&s=1763ab797979252a5963b724c5973b85ef31f9b6-
heal.journalNameJ Gastroenterol Hepatolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ