The effects of stress exposure on the hypothalamic-pituitary-adrenal axis, thymus, thyroid hormones and glucose levels
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kioukia-Fougia, N.
Antoniou, K.
Bekris, S.
Liapi, C.
Christofidis, I.
Papadopoulou-Daifoti, Z.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Prog Neuropsychopharmacol Biol Psychiatry
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
In the present study, an attempt was made to compare three stress models and their effects on the hypothalamic-pituitary-adrenal (HPA) axis, the thymus, the thyroid hormones and the glucose levels. The three different stress models were the chronic mild stress (CMS), the 14-day and the 1-day cold swim stress model. The CMS procedure caused a decrease in thymus weight and rendered no changes on glucose, the adrenocorticotropin hormone (ACTH) or the adrenals. Administration of imipramine (IMI) after the third week of CMS did not reverse the decrease in thymus weight. The 14-day cold swim stress doubled ACTH levels and the adrenal weight and reduced thymus weight, while total thyroxine (tT4), total triiodothyronine (tT3) and glucose levels were unaffected. IMI treatment restored the weights of the adrenal and thymus glands. One-day cold swim stress did not induce any statistically significant effect on the tested physiological parameters. The above findings indicate a distinct effect of the 14-day cold swim stress on HPA axis. Relative to CMS or the 14-day cold swim stress, no effect was induced by the 1-day cold swim stress. The IMI restoring effect, especially in the case of the 14-day cold swim stress, also suggests an association of antidepressant effect with the duration of drug treatment.
Περιγραφή
Λέξεις-κλειδιά
Adrenocorticotropic Hormone/blood, Animals, Blood Glucose/*metabolism, Cold Temperature, Hypothalamo-Hypophyseal System/metabolism/*physiopathology, Male, Organ Size, Pituitary-Adrenal System/metabolism/*physiopathology, Rats, Rats, Sprague-Dawley, Stress, Physiological/blood/*physiopathology, Thymus Gland/metabolism/*physiopathology, Thyroid Hormones/*blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12369253
http://ac.els-cdn.com/S0278584601002974/1-s2.0-S0278584601002974-main.pdf?_tid=eef78a1a3b2c4de529392e2c329539cd&acdnat=1332925211_8021f7f601a61770e9fd627e36dbbf14
http://ac.els-cdn.com/S0278584601002974/1-s2.0-S0278584601002974-main.pdf?_tid=eef78a1a3b2c4de529392e2c329539cd&acdnat=1332925211_8021f7f601a61770e9fd627e36dbbf14
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής