Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study

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dc.contributor.authorGiamarellos-Bourboulis, E. J.en
dc.contributor.authorTsangaris, I.en
dc.contributor.authorKanni, T.en
dc.contributor.authorMouktaroudi, M.en
dc.contributor.authorPantelidou, I.en
dc.contributor.authorAdamis, G.en
dc.contributor.authorAtmatzidis, S.en
dc.contributor.authorChrisofos, M.en
dc.contributor.authorEvangelopoulou, V.en
dc.contributor.authorFrantzeskaki, F.en
dc.contributor.authorGiannopoulos, P.en
dc.contributor.authorGiannikopoulos, G.en
dc.contributor.authorGialvalis, D.en
dc.contributor.authorGourgoulis, G. M.en
dc.contributor.authorKotzampassi, K.en
dc.contributor.authorKatsifa, K.en
dc.contributor.authorKofinas, G.en
dc.contributor.authorKontopidou, F.en
dc.contributor.authorKoratzanis, G.en
dc.contributor.authorKoulouras, V.en
dc.contributor.authorKoutsikou, A.en
dc.contributor.authorKoupetori, M.en
dc.contributor.authorKritselis, I.en
dc.contributor.authorLeonidou, L.en
dc.contributor.authorMega, A.en
dc.contributor.authorMylona, V.en
dc.contributor.authorNikolaou, H.en
dc.contributor.authorOrfanos, S.en
dc.contributor.authorPanagopoulos, P.en
dc.contributor.authorParamythiotou, E.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorPapanikolaou, X.en
dc.contributor.authorPavlaki, M.en
dc.contributor.authorPolychronopoulos, V.en
dc.contributor.authorSkoutelis, A.en
dc.contributor.authorTheodotou, A.en
dc.contributor.authorVassiliaghou, M.en
dc.contributor.authorDouzinas, E. E.en
dc.contributor.authorGogos, C.en
dc.contributor.authorArmaganidis, A.en
dc.contributor.authorHellenic Sepsis Study Grpen
dc.date.accessioned2015-11-24T18:38:22Z
dc.date.available2015-11-24T18:38:22Z
dc.identifier.issn0195-6701-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/17326
dc.rightsDefault Licence-
dc.subjectprocalcitoninen
dc.subjectprognosisen
dc.subjectsepsisen
dc.subjectventilator-associated pneumoniaen
dc.subjectcommunity-acquired pneumoniaen
dc.subjectrespiratory-tract infectionsen
dc.subjectcritically-ill patientsen
dc.subjectantibiotic-therapyen
dc.subjectdiagnosisen
dc.subjecttrialen
dc.subjectmetaanalysisen
dc.subjectguidanceen
dc.titleProcalcitonin as an early indicator of outcome in sepsis: a prospective observational studyen
heal.abstractThis study explores the role of procalcitonin (PCT) in predicting the outcome of sepsis. In a prospective multicentre observational investigation, blood was sampled within 24 h of onset of sepsis in 1156 hospitalised patients; 234 were in the intensive care unit (ICU) at the point of presentation of sepsis while 922 were not. PCT was estimated in serum by the ultrasensitive Kryptor assay in a double-blinded fashion. Among patients outside the ICU, mortality was 8% in those with PCT <= 0.12 ng/mL but 19.9% in those with PCT >0.12 ng/mL [P < 0.0001, odds ratio (OR) for death: 2.606; 95% confidence interval (CI): 1.553-4.371]. Among patients whose sepsis presented in ICU, mortality was 25.6% in those with PCT <= 0.85 ng/mL but 45.3% in those with PCT >0.85 ng/mL (P = 0.002; OR for death: 2.404; 95% CI: 1.385-4.171). It is concluded that PCT cut-off concentrations can contribute to predicting the outcome of sepsis and might be of particular value in identifying patients who would benefit from ICU admission. (C) 2010 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jhin.2010.07.026-
heal.identifier.secondary<Go to ISI>://000285621500012-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0195670110003853/1-s2.0-S0195670110003853-main.pdf?_tid=e038f0691732afab65dcf6b1883c5130&acdnat=1334230988_7856366c6342167a23eaecb3a28960d5-
heal.journalNameJournal of Hospital Infectionen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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