Leprosy and the natural selection for psoriasis
Φόρτωση...
Ημερομηνία
Συγγραφείς
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Med Hypotheses
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Psoriasis is a genetically determined, almost worldwide-distributed inflammatory skin disease with overall higher prevalence among people of northern European ancestry. Since enhanced innate immunity is an important feature of the pathophysiology of this disease, it has been proposed that differences in the prevalence of psoriasis in different populations mainly result from differences in natural selection for gene polymorphisms associated with more vigorous immunity against infectious agents. However the infectious agent(s) that could have acted upon human population as selection pressure for psoriasis is still obscure. Based on the remarkable clinical observation that psoriasis and leprosy are almost mutually exclusive, a fact that is further supported by divergent HLA patterns in patients with psoriasis and leprosy we propose that "resisting leprosy" may have been the evolutionary advantage that favoured the expansion of some psoriasis-associated genotypes especially in the progenitors of modern Europeans. Moreover, we suggest that the spreading out of a certain genetic resistance trait may offer a supplementary explanation for the better understanding of the relatively rapid decline of leprosy in the late medieval epoch in Europe. Both genetic and paleoepidemiologic methods could be employed in order to challenge the present hypothesis.
Περιγραφή
Λέξεις-κλειδιά
European Continental Ancestry Group/*genetics, Genetic Predisposition to Disease/*genetics, History, Medieval, Humans, Immunity, Innate/genetics/*immunology, Leprosy/epidemiology/genetics/*immunology, Mitogen-Activated Protein Kinase 3/metabolism, *Models, Immunological, Prevalence, Psoriasis/epidemiology/genetics/*immunology, Receptor, erbB-2/metabolism, *Selection, Genetic, Toll-Like Receptors/immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/22079652
http://ac.els-cdn.com/S0306987711005366/1-s2.0-S0306987711005366-main.pdf?_tid=b34e0c21ab8a151bc6242fd071674a6b&acdnat=1333700408_0ab5f41f8734231cd4ddb0548d45bd5a
http://ac.els-cdn.com/S0306987711005366/1-s2.0-S0306987711005366-main.pdf?_tid=b34e0c21ab8a151bc6242fd071674a6b&acdnat=1333700408_0ab5f41f8734231cd4ddb0548d45bd5a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής