Correlation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniation

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dc.contributor.authorZigouris, A.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorPachatouridis, D.en
dc.contributor.authorMihos, E.en
dc.contributor.authorDrosos, D.en
dc.contributor.authorFotakopoulos, G.en
dc.contributor.authorDoukas, M.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorKyritsis, A. P.en
dc.date.accessioned2015-11-24T19:26:45Z
dc.date.available2015-11-24T19:26:45Z
dc.identifier.issn1547-5646-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22756
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subject*Diskectomyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectIntervertebral Disc/*pathologyen
dc.subjectIntervertebral Disc Degeneration/*pathology/surgeryen
dc.subjectIntervertebral Disc Displacement/*pathology/surgeryen
dc.subjectLumbar Vertebrae/*pathology/surgeryen
dc.subjectMaleen
dc.subjectMatrix Metalloproteinase 1/*analysisen
dc.subjectMatrix Metalloproteinase 3/*analysisen
dc.subjectMiddle Ageden
dc.subjectStatistics as Topicen
dc.subjectYoung Adulten
dc.titleCorrelation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniationen
heal.abstractOBJECT: The authors studied the histological alterations and the expression of matrix metalloproteinase (MMP)-1 and MMP-3 in disc specimens of patients who had undergone operations for lumbar disc herniation. METHODS: Forty-three lumbar disc specimens were evaluated histopathologically for degenerative changes and immunohistochemical expression of MMP-1 and MMP-3. The observed degenerative changes provided a degenerative score that was applied in each patient. Sections of disc immunostained for MMP-1 and MMP-3 were evaluated semiquantitatively. Patients were categorized in 3 age groups: < 30 years, between 30 and 60 years, and > 60 years of age. The expression of MMP-1 and MMP-3 were correlated to patient's age, degenerative score, and grade of lumbar disc herniation. RESULTS: There was no statistically significant difference in the degenerative score between the age groups. Degenerative changes were more pronounced in greater grades of herniation (p < 0.0001). In the group of patients < 30 years of age there was a significant correlation between MMP-1 and MMP-3 expression and both degenerative score and herniation grade. For the group of patients 30-60 years of age, there was no significant difference between MMP-1 expression and degenerative score, but the correlation between MMP-1 expression and grade of herniation was significant. There was a significant correlation between MMP-3 expression and both degenerative score and herniation grade. Regarding the patients > 60 years of age, there was a significant correlation between MMP-1 and MMP-3 expression and both degenerative score and herniation grade. There was a significantly lower expression of both MMP-1 and MMP-3 in the group < 30 years of age compared with the other ages. No significant correlation was found in MMP-1 and MMP-3 expression between the groups of patients who were 30-60 and > 60 years of age. Interestingly, in age groups > 30 years, there were no statistically significant differences between the expression of MMP-1 and MMP-3, whereas in patients < 30 years of age the expression of MMP-3 was significantly lower than the expression of MMP-1. CONCLUSIONS: The expression of MMP-1 and MMP-3 were strongly correlated to the age of the patients and the grade of herniation. An important finding in this study is the differential expression of MMP-1 and MMP-3 between the age groups. In the young age group it appears that deregulation of MMP-1 expression is higher than that of MMP-3 in the pathogenesis of lumbar disc herniation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.3171/2010.9.SPINE09935-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21184636-
heal.journalNameJ Neurosurg Spineen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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