Μελέτη βιοχημικών παραγόντων στο εξωεμβρυϊκό υγρό
| dc.contributor.author | Παπαθεοδώρου, Στεφανία Η. | el |
| dc.date.accessioned | 2015-10-16T05:19:57Z | |
| dc.date.available | 2015-10-16T05:19:57Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/740 | |
| dc.identifier.uri | http://dx.doi.org/10.26268/heal.uoi.670 | |
| dc.rights | Default License | |
| dc.subject | Αμνιακό υγρό | el |
| dc.subject | Εξωεμβρυικό υγρό | el |
| dc.subject | Αντιμυλλεριανική ορμόνη (ΑΜΗ) | el |
| dc.subject | Ελεύθερη β-χοριακή γοναδοτροπίνη | el |
| dc.title | Μελέτη βιοχημικών παραγόντων στο εξωεμβρυϊκό υγρό | |
| dc.type | info:eu-repo/semantics/doctoralThesis | * |
| heal.abstract | Objectives: The present study aims to evaluate the concentration and distribution of pregnancy-associated plasma protein a (PAPP-A), free ?-HCG and anti-mullerian hormone (AMH) in amniotic fluid, coelomic fluid and maternal serum in the first trimester of pregnancy. Materials and Methods: Coelocentesis was performed in 56 women with singleton pregnancy from 6 to 10 weeks of gestation. The concentrations of PAPP-A and free ?-HCG were measured in the coelomic fluid and maternal serum and additionally AMH was measured in 10 women to which amniocentesis was also performed. Results: The median concentration of PAPP-A in maternal serum was 624.75 mU/I, significantly higher than the concentration in coelomic fluid (median 45.06 mU/I; p < 0.001). There is a significant correlation between the levels of PAPP-A in coelomic fluid and maternal serum (r=-0.6945, n=56, p=0.003). The concentration of maternal serum PAPP-A increased significantly with gestation (r=0.837, n=56, p=0.001). In most of our amniotic fluid samples the concentration of this protein was undetectable. The median concentration of free ?-HCG in maternal serum was 86.35 ng/ml, significantly lower than the concentration in coelomic fluid (median 1535 ng/ml; p <0.001). The levels of free ?-HCG in the coelomic fluid did not vary with gestation. The amniotic fluid concentration (median 24.865 ng/ml) was significantly lower that the one in maternal serum (p=0.005). The median concentration of AMH in maternal serum was 2.54 ng/ml. In coelomic fluid the median levels were 7.55 ng/ml, significantly higher than serum concentration (p=0.006) and amniotic fluid concentration (median 1.25ng/ml, p=0.005). Conclusion: The distribution of AMH in the compartments of the gestational sac in the first trimester may suggest another source of anti-mullerian hormone apart from the ovary during pregnancy. The distribution of PAPP-A is in contrast with the one described in other placental-derived proteins. The levels of free ?-HCG are significantly higher in coelomic fluid than in amniotic fluid and maternal serum and are consistent with its syncytiotrophoblast origin. | |
| heal.academicPublisher | Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής Τομέας Χειρουργικός. Κλινική Μαιευτική Γυναικολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων | |
| heal.academicPublisherID | uoi | |
| heal.access | free | |
| heal.advisorName | - | |
| heal.bibliographicCitation | Βιβλιογραφία: σ. 89-103 | el |
| heal.classification | Αμνιακό υγρό | |
| heal.committeeMemberName | Γεωργίου, Ιωάννης | el |
| heal.committeeMemberName | Μπερής, Αλέξανδρος | el |
| heal.committeeMemberName | Παρασκευαΐδης, Ευάγγελος | el |
| heal.committeeMemberName | Στέφος, Θεόδωρος | el |
| heal.committeeMemberName | Τσατσούλης, Αγαθοκλής | el |
| heal.committeeMemberName | Μακρυδήμας, Γεώργιος | el |
| heal.committeeMemberName | Ναυρόζογλου, Ιορδάνης | el |
| heal.fullTextAvailability | false | |
| heal.identifier.secondary | http://thesis.ekt.gr/thesisBookReader/id/26055#page/1/mode/2up | |
| heal.language | el | |
| heal.numberOfPages | 103 σ. | |
| heal.publicationDate | 2011 | |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής Τομέας Χειρουργικός. Κλινική Μαιευτική Γυναικολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων | |
| heal.type | doctoralThesis | |
| heal.type.el | Διδακτορική διατριβή | el |
| heal.type.en | Doctoral thesis | en |
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