Altered expression of cell cycle and apoptotic proteins in human liver pathologies

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dc.contributor.authorMitselou, A.en
dc.contributor.authorKarapiperides, D.en
dc.contributor.authorNesseris, I.en
dc.contributor.authorVougiouklakis, T.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:36:52Z
dc.date.available2015-11-24T19:36:52Z
dc.identifier.issn1791-7530-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23956
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subject*Apoptosisen
dc.subjectCarcinoma, Hepatocellular/metabolism/*pathologyen
dc.subjectCell Cycle Proteins/*metabolismen
dc.subjectCyclin-Dependent Kinase Inhibitor p21/metabolismen
dc.subjectFatty Liver/metabolism/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectKi-67 Antigen/metabolismen
dc.subjectLiver/metabolism/*pathologyen
dc.subjectLiver Cirrhosis/metabolism/*pathologyen
dc.subjectLiver Neoplasms/metabolism/*pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProto-Oncogene Proteins c-bcl-2/metabolismen
dc.subjectTumor Suppressor Protein p53/metabolismen
dc.subjectbcl-2-Associated X Protein/metabolismen
dc.titleAltered expression of cell cycle and apoptotic proteins in human liver pathologiesen
heal.abstractTauhe expression of cell cycle (P53, Ki-67, P21, and P27) and apoptotic proteins (BCL-2 and BAX) was investigated by immunohistochemistry in paraffin-embedded formalin-fixed tissues of normal and pathologic liver. An increased frequency of expression of P21 in cirrhosis and hepatocellular carcinoma (HCC) (p=0.003 and p=0.001 respectively) was found; P27 protein expression was more frequent in hepatitis (p=0.001) and HCC (p=0.003) when compared with normal tissue. BCL-2 protein was markedly more frequent in steatohepatitis (p<0.05) as compared to normal liver, in hepatitis cases (p=0.002) and in metastases (p<0.033). The expression of BAX was more frequent in hepatitis (p=0.001) and cirrhosis (p<0.001). We demonstrated in our study the expression of these proteins at different levels in liver pathologies. These findings have implications for understanding the evolution from liver inflammation to cirrhosis and associated carcinogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21115898-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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