Model investigations for vanadium-protein interactions: vanadium(III) compounds with dipeptides and their oxovanadium(IV) analogues

Απλή σελίδα τεκμηρίου
dc.contributor.authorTasiopoulos, A. J.en
dc.contributor.authorTolis, E. J.en
dc.contributor.authorTsangaris, J. M.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorWoollins, J. D.en
dc.contributor.authorSlawin, A. M. Z.en
dc.contributor.authorPessoa, J. C.en
dc.contributor.authorCorreia, I.en
dc.contributor.authorKabanos, T. A.en
dc.date.accessioned2015-11-24T16:41:57Z
dc.date.available2015-11-24T16:41:57Z
dc.identifier.issn0949-8257-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8494
dc.rightsDefault Licence-
dc.subjectvanadiumen
dc.subjectpeptidesen
dc.subjectcircular dichroismen
dc.subjectelectron paramagnetic resonanceen
dc.subjectsulfhydryl-containing pseudopeptidesen
dc.subjectsynthetic analogsen
dc.subjectcrystal-structureen
dc.subjectcomplexesen
dc.subjectchemistryen
dc.subjectpeptidesen
dc.subjectnitrogenaseen
dc.subjectbindingen
dc.subjectligandsen
dc.subjectepren
dc.titleModel investigations for vanadium-protein interactions: vanadium(III) compounds with dipeptides and their oxovanadium(IV) analoguesen
heal.abstractThe reaction of VCl3 with 1,10-phenanthroline and a series of dipeptides (H(2)dip), having aliphatic as well as aromatic side chains, in methyl alcohol and in the presence of triethylamine affords vanadium(III) compounds of the general formula [V-III(dip)(MeOH) (phen)]Cl. Aerial oxidation/hydrolysis of the vanadium(III) species gives their oxovanadium(IV) analogues of the general formula [(VO)-O-IV(dip)(phen)] X-ray crystallographic characterization of the [(VO)-O-IV(dip)(phen)] compounds (where dip(2-) = Gly-L-Ala, Gly-L-Val and Gly-L-Phe) revealed that the vanadium atom possesses a severely distorted octahedral coordination and is ligated to a tridentate dip(2-) ligand at the N-amine atom, the deprotonated N-peptide atom and one of the O-carboxylate atoms, as well as an oxo group and two phenanthroline nitrogen atoms. Circular dichroism characterization of the V-III/(VO2+)-O-IV-dipeptide compounds revealed a strong signal for the (VO2+)-O-IV species in the visible range of the spectrum, with a characteristic pattern which may be exploited to identify the N-am, N-pep and O-car ligation of a peptide or a protein to (VO2+)-O-IV center, and a weak Cotton effect of opposite sign to their vanadium(III) analogues. The visible spectra of the V-III-dipeptide compounds revealed two d-d bands with high intensity, thus indicating that the covalency of the metal-donor atoms is significant, i.e. the vanadium d orbitals are significantly mixed with the ligand orbitals, and this is confirmed by the low values of their Racah B parameters. The high-intensity band of the (VO2+)-O-IV-dipeptide compounds at similar to460 nm implies also a strong covalency of the metal with the equatorial donor atoms and this was supported by the EPR spectra of these compounds. Moreover, the V-III/(VO2+)-O-IV-dipeptide complexes were characterized by EPR and IR spectroscopies as well as conductivity and magnetic susceptibility measurements.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1007/s00775-001-0308-0-
heal.identifier.secondary<Go to ISI>://000174957800002-
heal.identifier.secondaryhttp://www.springerlink.com/content/te6xektmf6hyg4j8/fulltext.pdf-
heal.journalNameJournal of Biological Inorganic Chemistryen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2002-
heal.publisherSpringer Verlag (Germany)en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ