Systolic functional response of normal older and younger adult left ventricles to beta-blockade during exercise
| dc.contributor.author | Kyriakides, Z. S. | en |
| dc.contributor.author | Papaioannou, G. | en |
| dc.contributor.author | Paraskevaidis, I. A. | en |
| dc.contributor.author | Kolettis, T. M. | en |
| dc.contributor.author | Kremastinos, D. T. | en |
| dc.date.accessioned | 2015-11-24T19:43:15Z | |
| dc.date.available | 2015-11-24T19:43:15Z | |
| dc.identifier.issn | 0920-3206 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24734 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Aging/*physiology | en |
| dc.subject | Blood Pressure/drug effects | en |
| dc.subject | Echocardiography/drug effects | en |
| dc.subject | Electrocardiography/drug effects | en |
| dc.subject | Exercise/*physiology | en |
| dc.subject | Exercise Test | en |
| dc.subject | Female | en |
| dc.subject | Heart Rate/drug effects | en |
| dc.subject | Heart Ventricles/*drug effects | en |
| dc.subject | Humans | en |
| dc.subject | Injections, Intravenous | en |
| dc.subject | Male | en |
| dc.subject | Propranolol/administration & dosage/*pharmacology | en |
| dc.subject | Ventricular Function, Left/*drug effects | en |
| dc.title | Systolic functional response of normal older and younger adult left ventricles to beta-blockade during exercise | en |
| heal.abstract | There is controversy over the effects of beta-blockade on the left ventricular systolic response of the heart of the elderly to stress. In this study we compared the effects of acute beta-blockade in normal older and younger adult left ventricles during exercise. The study population consisted of 17 healthy elderly people, 67 +/- 3 years old, while 18 young normal subjects, 31 +/- 4 years old, served as controls. A symptom-limited exercise treadmill test was performed before and 15 minutes after intravenous administration of 0.12 mg propranolol/kg. M-mode echocardiographic studies were performed before and immediately after each test. Intravenous propranolol at rest decreased heart rate by 14 +/- 7 beats/min in the elderly and by 7.5 +/- 8 beats/min in the young (p = 0.02), decreased the double product by 2500 +/- 1200 mmHg/min and 1830 +/- 970 mmHg/min (p = 0.05), respectively; changed the left ventricular end-systolic dimension by +0.21 +/- 0.36 cm and +0.03 +/- 0.24 cm (p = 0.09), respectively; and changed the end-diastolic dimension by +0.22 +/- 0.46 cm in the elderly and by -0.02 +/- 0.32 cm in the young (p = 0.08). The change in fractional shortening was -1.22 +/- 4.17% in the elderly and -0.78 +/- 4.05% in the young (p > 0.05), and the decrease in the systolic blood pressure/end-systolic dimension ratio was 5.9 +/- 7 mmHg/cm and 4.3 +/- 3.8 mmHg/cm, respectively (p > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/7662595 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/m213u4j827606325/fulltext.pdf | - |
| heal.journalName | Cardiovasc Drugs Ther | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1995 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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