The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies
Φόρτωση...
Ημερομηνία
Συγγραφείς
Haidich, A. B.
Ioannidis, J. P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Clin Epidemiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: Clinical sites participating in multicenter trials may have unequal performance in recruiting subjects. We propose using the Gini coefficient as a quantitative measure of site accrual inequalities. STUDY DESIGN AND SETTING: We evaluated the relationship of this metric to other study characteristics across 166 clinical studies (27,865 subjects) conducted by the AIDS Clinical Trials Group between 1986 and 1999. RESULTS: Overall there was a modest recruitment inequality among clinical centers (mean Gini=0.33). In multivariate modeling, site accrual inequalities were higher when there was more protracted enrollment, and a larger number of sites and were lower in antiretroviral studies than other studies. In long-term studies, the site accrual inequality increased significantly over time (P=0.004). In efficacy trials, a higher Gini coefficient was associated with higher likelihood of the study results being statistically significant (P=0.010). CONCLUSION: The Gini coefficient may be easily and routinely incorporated in the description of the characteristics of a clinical study and may provide insights about its enrollment pattern.
Περιγραφή
Λέξεις-κλειδιά
Adult, Clinical Trials as Topic/*methods, HIV Infections/therapy, Humans, Logistic Models, Multicenter Studies as Topic/*methods, *Patient Selection, Randomized Controlled Trials as Topic/methods, Research Design
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15135834
http://ac.els-cdn.com/S0895435603003743/1-s2.0-S0895435603003743-main.pdf?_tid=1695aa9628ef772f56f45584e9bd13ed&acdnat=1333364442_5033404ec884136cc3363210bb3d4dee
http://ac.els-cdn.com/S0895435603003743/1-s2.0-S0895435603003743-main.pdf?_tid=1695aa9628ef772f56f45584e9bd13ed&acdnat=1333364442_5033404ec884136cc3363210bb3d4dee
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής