The Gini coefficient as a measure for understanding accrual inequalities in multicenter clinical studies
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Ημερομηνία
Συγγραφείς
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Clin Epidemiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: Clinical sites participating in multicenter trials may have unequal performance in recruiting subjects. We propose using the Gini coefficient as a quantitative measure of site accrual inequalities. STUDY DESIGN AND SETTING: We evaluated the relationship of this metric to other study characteristics across 166 clinical studies (27,865 subjects) conducted by the AIDS Clinical Trials Group between 1986 and 1999. RESULTS: Overall there was a modest recruitment inequality among clinical centers (mean Gini=0.33). In multivariate modeling, site accrual inequalities were higher when there was more protracted enrollment, and a larger number of sites and were lower in antiretroviral studies than other studies. In long-term studies, the site accrual inequality increased significantly over time (P=0.004). In efficacy trials, a higher Gini coefficient was associated with higher likelihood of the study results being statistically significant (P=0.010). CONCLUSION: The Gini coefficient may be easily and routinely incorporated in the description of the characteristics of a clinical study and may provide insights about its enrollment pattern.
Περιγραφή
Λέξεις-κλειδιά
Adult, Clinical Trials as Topic/*methods, HIV Infections/therapy, Humans, Logistic Models, Multicenter Studies as Topic/*methods, *Patient Selection, Randomized Controlled Trials as Topic/methods, Research Design
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/15135834
http://ac.els-cdn.com/S0895435603003743/1-s2.0-S0895435603003743-main.pdf?_tid=1695aa9628ef772f56f45584e9bd13ed&acdnat=1333364442_5033404ec884136cc3363210bb3d4dee
http://ac.els-cdn.com/S0895435603003743/1-s2.0-S0895435603003743-main.pdf?_tid=1695aa9628ef772f56f45584e9bd13ed&acdnat=1333364442_5033404ec884136cc3363210bb3d4dee
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής