Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma

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dc.contributor.authorBatistatou, A.en
dc.contributor.authorCharalabopoulos, A. K.en
dc.contributor.authorScopa, C. D.en
dc.contributor.authorNakanishi, Y.en
dc.contributor.authorKappas, A.en
dc.contributor.authorHirohashi, S.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T19:16:31Z
dc.date.available2015-11-24T19:16:31Z
dc.identifier.issn0945-6317-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21672
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*metabolism/pathologyen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCadherins/*metabolismen
dc.subjectCell Counten
dc.subjectColorectal Neoplasms/*metabolism/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectLymph Nodes/*metabolism/pathologyen
dc.subjectLymphatic Metastasis/pathologyen
dc.subjectMaleen
dc.subjectMembrane Glycoproteins/*metabolismen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Proteins/*metabolismen
dc.subjectTumor Markers, Biological/metabolismen
dc.titleExpression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinomaen
heal.abstractReduction/loss of E-cadherin is associated with the development and progression of many epithelial tumors, while in a limited number of neoplasms, E-cadherin is re-expressed in metastases. Dysadherin, recently characterized by members of our research team, has an anti-cell-cell adhesion function and downregulates E-cadherin in a posttranscriptional manner. Colorectal cancer (CRC) is one of the most common tumors in the developed world, and lymph node metastases are harbingers of aggressive behavior. The aim of the present study was to examine the dysadherin and E-cadherin expression patterns in lymph node metastases vs primary CRC. Dysadherin and E-cadherin expression was examined immunohistochemically in 78 patients with CRC, Dukes' stage C in the primary tumor and in one lymph node metastasis. Dysadherin was expressed in 42% while E-cadherin immunoreactivity was reduced in 45% of primary tumors. In lymph nodes, 33 and 81% of metastatic tumors were positive for dysadherin and E-cadherin, respectively. Dysadherin expression was not correlated with E-cadherin expression in the primary tumor with a reverse correlation evident in the lymph node metastases. Our results suggest that different mechanisms govern E-cadherin expression in the primary tumor and the corresponding lymph node metastases.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s00428-006-0183-8-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16570180-
heal.identifier.secondaryhttp://www.springerlink.com/content/018p5vp2k8q61238/fulltext.pdf-
heal.journalNameVirchows Archen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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