Association of TNFalpha, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility

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dc.contributor.authorLazaros, L. A.en
dc.contributor.authorXita, N. V.en
dc.contributor.authorChatzikyriakidou, A. L.en
dc.contributor.authorKaponis, A. I.en
dc.contributor.authorGrigoriadis, N. G.en
dc.contributor.authorHatzi, E. G.en
dc.contributor.authorGrigoriadis, I. G.en
dc.contributor.authorSofikitis, N. V.en
dc.contributor.authorZikopoulos, K. A.en
dc.contributor.authorGeorgiou, I. A.en
dc.date.accessioned2015-11-24T19:34:30Z
dc.date.available2015-11-24T19:34:30Z
dc.identifier.issn1939-4640-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23629
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectBase Sequenceen
dc.subjectCase-Control Studiesen
dc.subjectDNA Primersen
dc.subjectHumansen
dc.subjectInfertility, Male/geneticsen
dc.subjectMaleen
dc.subjectPolymerase Chain Reactionen
dc.subject*Polymorphism, Geneticen
dc.subjectReceptors, Tumor Necrosis Factor, Type I/*geneticsen
dc.subjectReceptors, Tumor Necrosis Factor, Type II/*geneticsen
dc.subject*Sperm Counten
dc.subjectSperm Motility/*geneticsen
dc.subjectTumor Necrosis Factor-alpha/*geneticsen
dc.titleAssociation of TNFalpha, TNFR1, and TNFR2 polymorphisms with sperm concentration and motilityen
heal.abstractTumor necrosis factor alpha (TNFalpha) is a multifunctional cytokine that regulates various cellular processes related to spermatogenesis. Two types of cell receptors, TNFR1 and TNFR2, mediate TNFalpha activity. In the present study, we sought to explore the association of TNFalpha -857C-->T, TNFR1 36A-->G, and TNFR2 676T-->G polymorphisms with sperm concentration and motility. Two hundred ninety men were examined during infertility investigation; of those, 170 men were normozoospermic and 120 were oligospermic. Polymerase chain reaction analysis revealed significant differences in genotype distribution of the TNFR1 36A-->G polymorphism between normozoospermic and oligospermic men. Men with oligozoospermia presented TNFR1 36A/A genotypes less frequently than normozoospermic men (P < .001). The presence of the TNFR1 36G allele was significantly increased in oligospermic men (P < .001). Furthermore, the presence of the TNFR1 36G allele was associated with lower sperm concentration in normozoospermic men (P < .03) and in the total study population (P < .001), and with lower sperm motility in normozoospermic men (P < .007) and in the total study population (P < .001). No significant associations were found between TNFalpha -857C-->T and TNFR2 676T-->G polymorphisms and semen quality. The TNFR1 36A allele is associated with increased sperm concentration and motility in our series, supporting the significance of TNFR1 gene in semen quality.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.2164/jandrol.110.011486-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21350240-
heal.identifier.secondaryhttp://www.andrologyjournal.org/cgi/content/abstract/33/1/74-
heal.journalNameJ Androlen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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