Photochemical transformation and wastewater fate and occurrence of omeprazole
Φόρτωση...
Ημερομηνία
Συγγραφείς
Albanis, Triantafyllos
Kosma, Christina
Lambropoulou, Dimitra
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Damia Barcelo
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Science of the Total Environment
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
HRMS for elucidation of transformation products and target
and suspect screening analysis in wastewaters
Περιγραφή
Omeprazole is one of the world-wide most frequently prescribed and administered pharmaceuticals in humans
for the relief of gastro-intestinal disorders. Despite its high worldwide consumption, omeprazole is rarely detect ed in urban wastewaters and environmental waters. On the other hand, its human urinary metabolites and trans formation products formed through abiotic processes in the environment have been recently documented.
Despite these available data, however, there is still a lack of information on the extent of environmental fate
and occurrence, on elimination mechanisms and efficiencies in waste water treatment plants. In this study, the
relevance of photodegradation processes on the environmental persistence of omeprazole under simulated
and solar irradiation was investigated. Photodegradation experiments were performed in distilled water, lake,
river and seawater, and revealed that the different matrix in natural waters significantly affect the photolytic be havior of the investigated compound. Overall, the results highlight that photodegradation process by solar irra diation significantly contributes to omeprazole degradation and elimination from the aquatic environment. TPs
formed through the process were identified and elucidated by using liquid chromatography high resolution
mass spectrometry. In total seven TPs were identified, among of which four were also detected as hydrolysis
TPs. The Microtox bioassay showed that solar photolysis is efficient to detoxify omeprazole and its TPs in aqueous
solutions. Finally, a systematic investigation was conducted in order to provide information on removal efficiency
and occurrence of omeprazole and its metabolites/TPs in 8 WWTPs in North West Greece by performing target
and suspect screening analysis. The findings revealed the presence of both parent compound and metabolites/
TPs in wastewaters. Given, however, the scarce detection of omeprazole at fairly low concentration levels, rom analytical and environmental point of view, further attention should be given to metabolites/TPs instead of
the parent compound.
Περιγραφή
Λέξεις-κλειδιά
Wastewaters, Hydrolysis, Omeprazole, Transformation products, Photodegradation, Metabolites
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Τμήμα Χημείας
Πίνακας περιεχομένων
Χορηγός
Βιβλιογραφική αναφορά
Περιλαμβάνει βιβλιογραφικές αναφορές
Ονόματα συντελεστών
Αριθμός σελίδων
Λεπτομέρειες μαθήματος
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Άδεια Creative Commons
Άδεια χρήσης της εγγραφής: Attribution-NonCommercial-NoDerivs 3.0 United States