Soluble interleukin-2 receptors in patients with advanced colorectal carcinoma

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dc.contributor.authorPavlidis, N.en
dc.contributor.authorNicolaides, C.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorKalef-Ezra, J.en
dc.contributor.authorAthanassiadis, A.en
dc.contributor.authorSeferiadis, C.en
dc.contributor.authorFountzilas, G.en
dc.date.accessioned2015-11-24T18:51:05Z
dc.date.available2015-11-24T18:51:05Z
dc.identifier.issn0393-6155-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18197
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectCA-19-9 Antigen/blooden
dc.subjectCarcinoembryonic Antigen/blooden
dc.subjectColorectal Neoplasms/immunology/mortality/*pathology/therapyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLymphatic Metastasisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Metastasisen
dc.subjectPredictive Value of Testsen
dc.subjectPrognosisen
dc.subjectReceptors, Interleukin-2/*analysisen
dc.subjectReference Valuesen
dc.subjectSex Factorsen
dc.subjectSurvival Analysisen
dc.subjectTime Factorsen
dc.subjectTumor Markers, Biological/*analysis/blooden
dc.titleSoluble interleukin-2 receptors in patients with advanced colorectal carcinomaen
heal.abstractThe levels of soluble interleukin-2 receptors (sIL-2R) were measured in the serum of 52 patients with advanced colorectal carcinoma and compared to CEA and CA 19-9 levels. Twenty-five normal, age and sex-matched individuals served as controls. Seventy-five per cent of the patients had increased mean serum levels of sIL-2R (1539 +/- 155 U/ml), while normal controls had mean levels of 555 +/- 31 U/ml (p < 0.001). The relationship with hepatic or lymph nodal metastases showed no statistically significant difference (p = 0.34 and p = 0.47, respectively). Serum sIL-2R levels showed a linear correlation with CEA (p < 0.05). Patients with lower pretreatment sIL-2R levels (less than 1.200 U/ml) had a longer survival than patients with higher initial levels (more than 1.200 U/ml) (p = 0.0049). In conclusion, the present work shows that the serum levels of sIL-2R: a) are elevated in patients with advanced colorectal cancer, b) have no relationship with the type of metastases, c) correlate with serum CEA and d) have a prognostic value for survival.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8740635-
heal.journalNameInt J Biol Markersen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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