Facile Synthesis of 2,3,6,11-Tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-Carboxylic Acid Methyl Ester via a 9-BBN-Mediated Tertiary Lactam Reduction

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dc.contributor.authorFokas, D.en
dc.contributor.authorWang, C. C.en
dc.date.accessioned2015-11-24T17:34:19Z
dc.date.available2015-11-24T17:34:19Z
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/13948
dc.rightsDefault Licence-
dc.subject9-BBNen
dc.subjectDimethyl α-ketoglutarateen
dc.subjectlactam reductionen
dc.subjecttryptamineen
dc.titleFacile Synthesis of 2,3,6,11-Tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-Carboxylic Acid Methyl Ester via a 9-BBN-Mediated Tertiary Lactam Reductionen
heal.abstractA facile synthesis of 2,3,6,11-tetrahydro-1H,5H-indolizino[8,7-b]indole-11b-carboxylic acid methyl ester, a versatile intermediate utilized in the synthesis of indole alkaloids, was achieved in two steps. Condensation of tryptamine with dimethyl α-ketoglutarate led to the formation of the corresponding indolizino[8,7-b]indolone ester, which subsequently underwent an efficient lactam reduction with 9-BBN to generate the tertiary amine ester in good yield.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryhttp://dx.doi.org/10.1080/00397910802238684-
heal.identifier.secondaryhttp://www.ingentaconnect.com/content/tandf/lsyc/2008/00000038/00000021/art00023-
heal.journalNameSynth. Commun.en
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.publisherTaylor and Francis Ltden
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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