Expression of EGF, TGF-alpha and EGFR in squamous cell lung carcinomas

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dc.contributor.authorGorgoulis, V.en
dc.contributor.authorAninos, D.en
dc.contributor.authorMikou, P.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorKarameris, A.en
dc.contributor.authorJoardanoglou, J.en
dc.contributor.authorRasidakis, A.en
dc.contributor.authorVeslemes, M.en
dc.contributor.authorOzanne, B.en
dc.contributor.authorSpandidos, D. A.en
dc.date.accessioned2015-11-24T19:16:41Z
dc.date.available2015-11-24T19:16:41Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21697
dc.rightsDefault Licence-
dc.subjectCarcinoma, Squamous Cell/*chemistryen
dc.subjectEpidermal Growth Factor/*analysisen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLung Neoplasms/*chemistryen
dc.subjectReceptor, Epidermal Growth Factor/*analysisen
dc.subjectTransforming Growth Factor alpha/*analysisen
dc.titleExpression of EGF, TGF-alpha and EGFR in squamous cell lung carcinomasen
heal.abstractImmunohistochemical study of epidermal growth factor (EGF), epidermal growth factor receptor (EGFR) and transforming growth factor-alpha (TGF-alpha) expression was performed on paraffin-embedded tissue specimens of 70 squamous cell lung carcinomas. The carcinomas were placed to one of the following eight groups, according to the results of EGF, TGF-alpha and EGFR expression: group 1: none, group 2: only EGFR, group 3: EGFR and TGF-alpha, group 4: EGFR and EGF, group 5: TGF-alpha and EGF, group 6: all three, group 7: only TGF-alpha and finally group 8: only EGF. Statistical analysis of the results revealed that the ratio of squamous cell lung carcinomas with lymph node metastasis was significantly higher in groups 4, 5 and 6 (P less than 0.01). We also examined whether EGF receptors were truncated with the use of two monoclonal antibodies directed against different portions of the receptor (EGFR1 and F4). No truncated EGF receptors were detected. These results suggest that lung carcinomas expressing the molecules EGF/EGFR, TFG-alpha/EGFR or TGF/alpha/EGF/EGFR display pathologic features of more aggressive disease.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/1503407-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1992-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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