Relationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosus

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dc.contributor.authorDueymes, M.en
dc.contributor.authorBarrier, J.en
dc.contributor.authorBesancenot, J. F.en
dc.contributor.authorCledes, J.en
dc.contributor.authorConri, C.en
dc.contributor.authorDien, G.en
dc.contributor.authorDrosos, A. A.en
dc.contributor.authorDueymes, J. M.en
dc.contributor.authorGalanaud, P.en
dc.contributor.authorGrobois, B.en
dc.contributor.authoret al.,en
dc.date.accessioned2015-11-24T18:54:30Z
dc.date.available2015-11-24T18:54:30Z
dc.identifier.issn1018-2438-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18691
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntibodies, Antinuclear/*blooden
dc.subjectDNA/*immunologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoglobulin Isotypes/classificationen
dc.subjectInterleukin-4/*blooden
dc.subjectLupus Erythematosus, Systemic/blood/*immunologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.titleRelationship of interleukin-4 to isotypic distribution of anti-double-stranded DNA antibodies in systemic lupus erythematosusen
heal.abstractIgG subclasses of anti-double-stranded DNA antibodies were determined in 182 patients with systemic lupus erythematosus. All isotypes were detected, but IgG1 and IgG3 were predominant (62 and 51% of the cases, respectively). An average of 64 +/- 27% was IgG1, 16 +/- 22% IgG2, 16 +/- 19% IgG3 and 4 +/- 10% IgG4. The rank order or frequency was IgG1, IgG3, IgG2 and IgG4 in patients with musculoskeletal involvement; IgG1, IgG2, IgG3 and IgG4 in those with renal complications; IgG3, IgG1, IgG2 and IgG4 in those with cutaneous involvement; and IgG1, IgG3, IgG2 and IgG4 in those with hematological manifestations. Interleukin-4 (IL-4) was detectable in 17 of 36 selected patients, as opposed to 1 of 40 normal controls. The percentage of the total autoantibody contributed by IgG1 was significantly higher (p < 0.03) in these patients than in the remainder with undetectable levels of IL-4.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8353462-
heal.identifier.secondaryhttp://content.karger.com/ProdukteDB/produkte.asp?doi=10.1159/000236484-
heal.journalNameInt Arch Allergy Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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