Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level
Φόρτωση...
Ημερομηνία
Συγγραφείς
Stefanis, N. C.
Trikalinos, T. A.
Avramopoulos, D.
Smyrnis, N.
Evdokimidis, I.
Ntzani, E. E.
Ioannidis, J. P.
Stefanis, C. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Biol Psychiatry
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Aspects of cognitive function and schizotypy have been proposed as potential endophenotypes for schizophrenia. It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia. METHODS: We examined the potential impact of 18 single nucleotide polymorphisms (SNPs) within the DTNBP1, NRG1, DAOA/G32, and DAAO genes, on cognition and self-rated schizotypy, in a representative population of 2243 young male military conscripts. Single SNP and haplotype associations were evaluated. RESULTS: The DTNBP1 SNPs rs2619522 and rs760761 exhibited several single marker associations, the minor alleles being associated with lower attention capacity but also a decrease in positive and paranoid schizotypy scores. The DTNBP1 haplotype load had borderline associations with nonverbal IQ, paranoid schizotypy, and sustained attention. For individual NRG1 polymorphisms, isolated but weak signals of association were noted with sustained attention and working memory but not schizotypy. The risk allele of functional SNP8NRG243177 was associated with reduced spatial working memory capacity. An isolated effect of DAAO haplotype variability was noted on negative and disorganization schizotypy. No convincing association of DAOA/G32 variability was detected. CONCLUSIONS: The DTNBP1 and, less so, NRG1 and DAAO variants might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Alleles, Carrier Proteins/*genetics/physiology, Cognition/*physiology, DNA/genetics, Genotype, Haplotypes, Humans, Intelligence Tests, Linkage Disequilibrium/genetics, Male, Neuregulin-1/genetics/physiology, Neuropsychological Tests, Personality Tests, Phenotype, Polymorphism, Single Nucleotide, Population, Risk, Schizophrenia/*genetics, *Schizophrenic Psychology, Schizotypal Personality Disorder/*genetics/*psychology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17336946
http://ac.els-cdn.com/S0006322306014879/1-s2.0-S0006322306014879-main.pdf?_tid=666fa027bad64022ec05f75a2b8414bb&acdnat=1333363951_3394e3a6029e900b183a92513de96311
http://ac.els-cdn.com/S0006322306014879/1-s2.0-S0006322306014879-main.pdf?_tid=666fa027bad64022ec05f75a2b8414bb&acdnat=1333363951_3394e3a6029e900b183a92513de96311
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής