Interferon-gamma release assay clarifies the effect of bacille Calmette-Guerin vaccination in Greek army recruits

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dc.contributor.authorKatsenos, S.en
dc.contributor.authorNikolopoulou, M.en
dc.contributor.authorKonstantinidis, A. K.en
dc.contributor.authorGartzonika, C.en
dc.contributor.authorGogali, A.en
dc.contributor.authorMargelis, I.en
dc.contributor.authorTatsioni, A.en
dc.contributor.authorMavridis, A.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorDaskalopoulos, G.en
dc.date.accessioned2015-11-24T19:09:28Z
dc.date.available2015-11-24T19:09:28Z
dc.identifier.issn1815-7920-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20705
dc.rightsDefault Licence-
dc.subjectAdjuvants, Immunologic/administration & dosageen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectBCG Vaccine/*administration & dosageen
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectInterferon-gamma/*diagnostic useen
dc.subjectMaleen
dc.subjectMilitary Personnelen
dc.subjectTuberculin Test/*methodsen
dc.subjectTuberculosis/*diagnosis/immunologyen
dc.subjectYoung Adulten
dc.titleInterferon-gamma release assay clarifies the effect of bacille Calmette-Guerin vaccination in Greek army recruitsen
heal.abstractOBJECTIVE: To compare the most recent commercial interferon-gamma release assay (IGRA), the QuantiFERON-TB Gold In-Tube (QFT-GIT), with the tuberculin skin test (TST) in Greek army recruits who were bacille Calmette-Guerin (BCG) vaccinated during childhood and had no history of tuberculosis (TB) exposure. METHOD: We conducted a cross-sectional comparison study of 1750 young army recruits. TST was performed on all participants, while QFT-GIT was performed in all subjects with TST > 0 mm and in 18 TST-negative controls (TST = 0 mm). RESULTS: Among the study subjects, 5.4% (96/1750) had TST indurations of >or=10 mm, and 3.4% (59/1750) had indurations of >or=15 mm. Among subjects with a positive TST, 11.4% (11/96) tested positive on QFT-GIT. All those with QFT-GIT positivity had TST indurations of >or=15 mm, and none of those with TST indurations of 10-14 mm were positive by QFT-GIT. The overall agreement between TST and QFT-GIT was poor (kappa = 0.02). CONCLUSION: We found a significant discordance between TST and QFT-GIT in BCG-vaccinated Greek army recruits consistent with previous studies showing that BCG received after infancy produces false-positive TST reactions. Our findings underline the need for a two-step approach in diagnosing latent TB infection in all BCG-vaccinated individuals: initial TST screening, followed by an IGRA to confirm TST positivity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20392346-
heal.journalNameInt J Tuberc Lung Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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