Prothrombotic state, cardiovascular, and metabolic syndrome risk factors in prepubertal children born large for gestational age

Απλή σελίδα τεκμηρίου
dc.contributor.authorEvagelidou, E. N.en
dc.contributor.authorGiapros, V. I.en
dc.contributor.authorChalla, A. S.en
dc.contributor.authorCholevas, V. K.en
dc.contributor.authorVartholomatos, G. A.en
dc.contributor.authorSiomou, E. C.en
dc.contributor.authorKolaitis, N. I.en
dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorAndronikou, S. K.en
dc.date.accessioned2015-11-24T18:55:53Z
dc.date.available2015-11-24T18:55:53Z
dc.identifier.issn1935-5548-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18947
dc.rightsDefault Licence-
dc.subjectBirth Weight/*physiologyen
dc.subjectCardiovascular Diseases/*epidemiologyen
dc.subjectChilden
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectGestational Ageen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/*epidemiologyen
dc.subjectRegression Analysisen
dc.subjectThrombosis/*epidemiologyen
dc.titleProthrombotic state, cardiovascular, and metabolic syndrome risk factors in prepubertal children born large for gestational ageen
heal.abstractOBJECTIVE: To evaluate metabolic syndrome and cardiovascular disease risk factors in prepubertal children born large for gestational age (LGA) to nondiabetic, nonobese mothers. RESEARCH DESIGN AND METHODS: At 6-7 years of age, the comparison of various factors was made between 31 LGA and 34 appropriate-for-gestational-age (AGA) children: fibrinogen, antithrombin III, protein C and S, fasting insulin, glucose, homeostasis assessment model of insulin resistance (HOMA-IR) index, adiponectin, leptin, visfatin, IGF-1, IGF-binding protein (IGFBP)-1, IGFBP-3, lipids, and the genetic factors V Leiden G1691A mutation, prothrombin 20210A/G polymorphism, and mutation in the enzyme 5,10-methylenetetrahydrofolate-reductase gene (MTHFR-C677T). RESULTS: LGA children had higher levels of leptin (P<0.01), fasting insulin (P<0.01), and HOMA-IR (P<0.01), but lower IGFBP-3 (P=0.0001), fibrinogen (P=0.0001), and lipoprotein(a) (P<0.001) than AGA children. Significantly more LGA children were homozygous for the MTHFR-C677T mutation (P=0.0016). CONCLUSIONS: Being born LGA to nondiabetic, nonobese mothers is associated with diverse effects on cardiometabolic risk factors at prepuberty.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.2337/dc10-1190-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20724652-
heal.identifier.secondaryhttp://care.diabetesjournals.org/content/33/11/2468.full.pdf-
heal.journalNameDiabetes Careen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ