Anionic mechanisms of zinc uptake across the human red cell membrane
| dc.contributor.author | Kalfakakou, V. | en |
| dc.contributor.author | Simons, T. J. | en |
| dc.date.accessioned | 2015-11-24T19:36:11Z | |
| dc.date.available | 2015-11-24T19:36:11Z | |
| dc.identifier.issn | 0022-3751 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23827 | |
| dc.rights | Default Licence | - |
| dc.subject | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid | en |
| dc.subject | 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid/analogs & | en |
| dc.subject | derivatives/blood | en |
| dc.subject | Anions/*blood | en |
| dc.subject | Bicarbonates/blood | en |
| dc.subject | Cations, Divalent/blood | en |
| dc.subject | Cations, Monovalent/blood | en |
| dc.subject | Erythrocyte Membrane/*metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Lead/blood | en |
| dc.subject | Salicylic Acid | en |
| dc.subject | Salicylic Acids/blood | en |
| dc.subject | Thiocyanates/blood | en |
| dc.subject | Zinc/*blood | en |
| dc.title | Anionic mechanisms of zinc uptake across the human red cell membrane | en |
| heal.abstract | 1. Zinc is taken up into human red cells by two mechanisms that depend upon the presence of anions. One of these requires bicarbonate ions, is inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulphonic acid (DIDS) and appears to be catalysed by the anion exchanger. The second occurs in the presence of thiocyanate or salicylate ions and may represent transport of a neutral complex with Zn2+. 2. The initial rate of Zn2+ uptake via the anion exchanger is 64 +/- 13 mumol (10(13) cells x h)-1 microM-1 external Zn2+, in the presence of 5 mM-bicarbonate at pH 7.4 and 37 degrees C (+/- S.D.). This is about 1/250 of the corresponding rate of Pb2+ uptake by the anion exchanger. 3. The variation of transport with Zn2+ concentration, HCO3- concentration and pH suggests that the transported species may be ZnCO3Cl- or Zn(HCO3)Cl.OH-. 4. Zinc efflux could not be observed by either of the above routes. This observation suggests that the intracellular free Zn2+ concentration is below 3 nM. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2161459 | - |
| heal.journalName | J Physiol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1990 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: