Fetal immunodeficiency: a consequence of placental insufficiency
| dc.contributor.author | Thilaganathan, B. | en |
| dc.contributor.author | Plachouras, N. | en |
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T19:15:56Z | |
| dc.date.available | 2015-11-24T19:15:56Z | |
| dc.identifier.issn | 0306-5456 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21588 | |
| dc.rights | Default Licence | - |
| dc.subject | CD4-CD8 Ratio | en |
| dc.subject | Cross-Sectional Studies | en |
| dc.subject | Female | en |
| dc.subject | *Fetal Blood | en |
| dc.subject | Fetal Growth Retardation/*blood/etiology | en |
| dc.subject | Humans | en |
| dc.subject | Hydrogen-Ion Concentration | en |
| dc.subject | Leukocyte Count | en |
| dc.subject | Placental Insufficiency/*complications | en |
| dc.subject | Pregnancy | en |
| dc.subject | T-Lymphocytes | en |
| dc.title | Fetal immunodeficiency: a consequence of placental insufficiency | en |
| heal.abstract | OBJECTIVE: To study the effect of placental insufficiency on fetal lymphocyte subpopulations. STUDY DESIGN: Cross sectional study of 19 growth retarded fetuses undergoing cordocentesis at 24 to 37 weeks gestation. Flow cytometry was used to enumerate fetal blood lymphocyte subpopulations. RESULTS: The mean T (CD3+), B (CD19+), T-helper (CD4+), T-suppressor/cytotoxic (CD8+) cell counts and the CD4 to CD8 ratio in the growth retarded fetuses were significantly lower than respective normal mean for gestation (CD3+: z = 3.66, P < 0.001; CD19+: z = 2.18, P < 0.05; CD4+: z = 3.76, P < 0.001; CD8+: z = 2.26, P < 0.05; and CD4/CD8: z = 2.27, P < 0.05). There were significant associations between the decrease in the T lymphocyte subpopulations and the degree of fetal acidaemia. CONCLUSIONS: Growth retarded fetuses demonstrate immune abnormalities that could be attributed to intrauterine starvation. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8251449 | - |
| heal.journalName | Br J Obstet Gynaecol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1993 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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