Germ cell transplantation: a review and progress report on ICSI from spermatozoa generated in xenogeneic testes

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dc.contributor.authorSofikitis, N.en
dc.contributor.authorKaponis, A.en
dc.contributor.authorMio, Y.en
dc.contributor.authorMakredimas, D.en
dc.contributor.authorGiannakis, D.en
dc.contributor.authorYamamoto, Y.en
dc.contributor.authorKanakas, N.en
dc.contributor.authorKawamura, H.en
dc.contributor.authorGeorgiou, J.en
dc.contributor.authorSchrader, M.en
dc.contributor.authorLolis, E.en
dc.contributor.authorGiannakopoulos, X.en
dc.contributor.authorLoutradis, D.en
dc.contributor.authorTarlatzis, V.en
dc.contributor.authorMiyagawa, I.en
dc.date.accessioned2015-11-24T19:14:47Z
dc.date.available2015-11-24T19:14:47Z
dc.identifier.issn1355-4786-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21389
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectCell Transplantation/methodsen
dc.subjectCryopreservationen
dc.subjectHumansen
dc.subjectKineticsen
dc.subjectMaleen
dc.subjectMeiosis/physiologyen
dc.subjectSeminiferous Tubulesen
dc.subject*Sperm Injections, Intracytoplasmicen
dc.subjectSpermatogenesis/physiologyen
dc.subject*Spermatozoa/cytology/*transplantationen
dc.subjectTestis/*physiologyen
dc.subjectTissue Donorsen
dc.subject*Transplantation, Heterologousen
dc.titleGerm cell transplantation: a review and progress report on ICSI from spermatozoa generated in xenogeneic testesen
heal.abstractResults from the transplantation of donor male germ cells into xenogeneic recipient seminiferous tubules indicate that donor spermatogonia are capable of differentiating to form spermatozoa morphologically characteristic of the donor species. Germ cell transplantation procedures combined with developments in freezing, culturing or enriching germ cell populations have applications of paramount importance in medicine, basic sciences and animal reproduction. Additionally, these techniques can serve as an alternative approach for gonadal protection and fertility preservation in patients with cancer. This article is a chronological critical review of the technological advances that followed the initial successful transplantation of mouse germ cells into recipient mice. Furthermore, the factors responsible for the immunological privilege properties of the testis and the parameters influencing the potential of mammalian germ cells to undergo mitosis and meiosis within a xenogeneic testis are described. Finally, the role of human germ cell transplantation procedures in the therapeutic management of non-obstructive azoospermia is discussed.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12859049-
heal.journalNameHum Reprod Updateen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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