Distensibility and pulse wave velocity of the thoracic aorta in patients with juvenile idiopathic arthritis: An MRI study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Argyropoulou, M. I.
Kiortsis, D. N.
Daskas, N.
Xydis, V.
Mavridis, A.
Efremidis, S. C.
Siamopoulou, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Exp Rheumatol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objective. An increased incidence of cardiovascular disease has been found in rheumatic disorders. Changes in the variables of aortic elasticity in patients with juvenile idiopathic arthritis (JIA) were evaluated and their relationship to inflammation, anti-rheumatic drugs and traditional cardiovascular risk factor's were investigated in this study Methods. Phase contrast MR was performed in 31 patients with JIA and 28 age and sex matched controls to evaluate the aortic distensibility, and pulse wave velocity (PWV). Disease activity, variables, plasma lipid profile, homocysteine, thyroid hormones, glucose and insulin were assessed in the patients. Results. Eighteen patients had oligoarticular 6 polyarticular and 7 systemic disease. Distensibility, was lower (mean: 10.25; SD: 4.18) and PWV was higher (mean: 3.68; SD: 1.59) in the patients compared to the controls (mean: 13.4; SD: 4,99), (mean: 1.38; SD: 0.54) respectively (p < 0.01). A positive correlation between PWV and age was observed ill the patients (r(s) = 0.47, p < 0.01) and controls (r(s) = 0.72, p < 0.01), and a negative correlation between distensibility, and age in the patients (r(s) = -0.59, p < 0.01) and controls (r(s) = -0.63, p < 0.01). No statistically significant correlations were found between distensibility and PWV and metabolic and disease activity parameters. When distensibility and PWV were adjusted for age no significant differences were found between the three subtypes of JIA. Conclusion. JIA is associated with increased aortic stiffness that might suggest subclinical atherosclerosis. Early detection and follow-up by noninvasive methods may be useful in the prevention of future cardiovascular disease.
Περιγραφή
Λέξεις-κλειδιά
juvenile idiopathic arthritis, aorta, atherosclerosis, mri, pulse wave velocity, distensibility, coronary-artery disease, c-reactive protein, rheumatoid-arthritis, cardiovascular-disease, marfan-syndrome, heart-disease, risk-factors, atherosclerosis, age, hypercholesterolemia
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000187282800020
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής