Prognostic significance of thymidine phosphorylase in superficial bladder carcinoma
Φόρτωση...
Ημερομηνία
Συγγραφείς
Stavropoulos, N. E.
Bouropoulos, C.
Ioachim, E.
Michael, M.
Hastazeris, K.
Tsimaris, I.
Kalogeras, D.
Liamis, Z.
Kafarakis, V.
Stefanaki, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int Urol Nephrol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objective: We investigated the expression of thymidine phosphorylase (TP) in bladder carcinomas and assessed its prognostic significance in superficial bladder cancer samples. Patients and methods: We studied 142 primary bladder cancer samples immunohistochemically for nuclear thymidine phosphorylase (TPN), cytoplasmic (TPC) and stromal (TPSTR) expression. We correlated them with standard clinicopathological features (grade, stage, concurrent in situ, multiplicity, primary or recurrent status), as well with recurrence and progression. We examined also the relationship between TP and tumor microvessel density. Results: The level of all types of TP correlated well with stage, while grade correlated well only with TPSTR and the presence of carcinoma in situ only with TPN. Patients with low levels of TPN had a longer tumor free interval, during a 38.6 months mean follow up time. Regarding the association between TP count and microvessel density we found the strongest association with TPSTR (p=0.003), a borderline statistical significance with TPC (p=0.049) and no relationship with TPN (p=0.072). Conclusions: We suggest that the assessment of TPN might be useful for predicting recurrence in superficial bladder cancer. We propose also that TP may stimulate angiogenesis.
Περιγραφή
Λέξεις-κλειδιά
Aged, Carcinoma, Transitional Cell/*metabolism/pathology, Cell Nucleus/metabolism, Cytoplasm/metabolism, Disease Progression, Female, Humans, Immunohistochemistry, Male, Middle Aged, Prognosis, Proportional Hazards Models, Retrospective Studies, Thymidine Phosphorylase/*metabolism, Urinary Bladder Neoplasms/*metabolism/pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16132760
http://www.springerlink.com/content/h8083r46v44k4u71/fulltext.pdf
http://www.springerlink.com/content/h8083r46v44k4u71/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής