Uric acid levels and atrial fibrillation in hypertensive patients

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dc.contributor.authorLiu, T.en
dc.contributor.authorZhang, X.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorWang, S.en
dc.contributor.authorLi, G.en
dc.date.accessioned2015-11-24T18:57:06Z
dc.date.available2015-11-24T18:57:06Z
dc.identifier.issn1349-7235-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19132
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAtrial Fibrillation/*blood/*etiology/physiopathology/ultrasonographyen
dc.subjectBiological Markers/blooden
dc.subjectCreatinine/blooden
dc.subjectCross-Sectional Studiesen
dc.subjectEchocardiographyen
dc.subjectFemaleen
dc.subjectGlomerular Filtration Rateen
dc.subjectHeart Atria/ultrasonographyen
dc.subjectHumansen
dc.subjectHypertension/*blood/*complications/physiopathology/ultrasonographyen
dc.subjectInflammation Mediators/blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOxidative Stressen
dc.subjectRisk Factorsen
dc.subjectUric Acid/*blooden
dc.subjectVentricular Function, Leften
dc.titleUric acid levels and atrial fibrillation in hypertensive patientsen
heal.abstractOBJECTIVE: Uric acid (UA) is a cardiovascular risk marker associated with oxidative stress and inflammation. Recently, atrial fibrillation (AF) has been associated with inflammation and oxidative stress. The objective of this observational study was to investigate the association between UA levels and AF in hypertensive patients. METHODS: Consecutive patients with hypertension were screened. We excluded subjects with coronary artery disease, congestive heart failure, diabetes, valvular heart disease, congenital heart disease, cardiomyopathy, renal failure, inflammatory conditions, thyroid dysfunction, respiratory diseases, and those who were taking drugs that affect UA metabolism (apart from diuretics). The final study population consisted of 451 patients. Fifty of them (11%) had AF (paroxysmal: 38; persistent: 8; permanent: 4). Demographic, clinical, laboratory, and echocardiographic characteristics were carefully recorded. RESULTS: After univariate analysis, age, duration of hypertension, serum creatinine, serum UA, left atrial diameter (LAD), interventricular septum thickness, and left ventricular posterior wall thickness were significantly increased in patients with AF compared with non-AF patients, while the estimated glomerular filtration (eGFR) level was much lower in patients with AF than in those without AF. After multivariate logistic regression analysis, the independent predictors of AF were UA (OR: 1.008; 95% CI: 1.003-1.013, p=0.002) and LAD (OR: 1.160; 95% CI: 1.068-1.260; p<0.001). CONCLUSION: We demonstrated an independent association between increased serum UA levels and AF in hypertensive patients. Undoubtedly, larger studies in different populations should further examine this potential association as well as the underlying pathophysiological mechanisms.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21498925-
heal.journalNameIntern Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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