MRI of the liver and the pituitary gland in patients with beta-thalassemia major: Does hepatic siderosis predict pituitary iron deposition?
| dc.contributor.author | Argyropoulou, M. I. | en |
| dc.contributor.author | Kiortsis, D. N. | en |
| dc.contributor.author | Efremidis, S. C. | en |
| dc.date.accessioned | 2015-11-24T19:03:25Z | |
| dc.date.available | 2015-11-24T19:03:25Z | |
| dc.identifier.issn | 0938-7994 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19897 | |
| dc.rights | Default Licence | - |
| dc.subject | magnetic resonance imaging | en |
| dc.subject | liver | en |
| dc.subject | pituitary gland | en |
| dc.subject | beta-thalassemia major | en |
| dc.subject | iron | en |
| dc.subject | magnetic-resonance | en |
| dc.subject | overload | en |
| dc.subject | hemochromatosis | en |
| dc.subject | diagnosis | en |
| dc.subject | quantification | en |
| dc.subject | ferritin | en |
| dc.subject | children | en |
| dc.subject | disease | en |
| dc.title | MRI of the liver and the pituitary gland in patients with beta-thalassemia major: Does hepatic siderosis predict pituitary iron deposition? | en |
| heal.abstract | Our objective was to study, in thalassemic patients, if hepatic siderosis evaluated by MRI could predict the pituitary iron overload. In 36 thalassemic patients (age range 6-44 years, mean age 21.7 years) the liver/fat ratio (L/F), the pituitary/fat ratio (P/F), the liver and pituitary T2 relaxation times were evaluated, by using a multiecho spin-echo sequence. Serum ferritin levels were measured and an extensive endocrine evaluation was performed. The L/F, the P/F and pituitary T2 showed a good correlation with serum ferritin (r=-0.55, r=-0.55 and r=-0.53, respectively; p<0.01). Liver T2 did not show significant correlation with serum ferritin. The variability of L/F explained only the 10.8% of the variability of pituitary T2 and of the WE When ferritin was added to the model it predicted only the 26.85% and the 30.8% of the variability of pituitary T2 and of the P/F, respectively. The P/F and pituitary T2 were lower in patients with hypogonadotropic hypogonadism (group 1) compared with those without pituitary dysfunction (group 2). No significant differences of L/F were found between the two groups. Hepatic iron overload evaluated by MR is a poor predictor of pituitary siderosis. The MR studies of the pituitary gland might be necessary to evaluate the pituitary iron overload. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1007/s00330-002-1421-3 | - |
| heal.identifier.secondary | <Go to ISI>://000180891000003 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/fe8v0n9ba00xm8dd/fulltext.pdf | - |
| heal.journalName | European Radiology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2003 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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