Statins and renal function

Απλή σελίδα τεκμηρίου
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorMikhailidis, D. P.en
dc.date.accessioned2015-11-24T18:50:38Z
dc.date.available2015-11-24T18:50:38Z
dc.identifier.issn0003-3197-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18117
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAlbuminuria/prevention & controlen
dc.subjectAnimalsen
dc.subjectAnticholesteremic Agents/pharmacology/therapeutic useen
dc.subjectArteriosclerosis/complicationsen
dc.subjectCardiovascular Diseases/complications/drug therapyen
dc.subjectClinical Trials as Topicen
dc.subjectCreatinine/blooden
dc.subjectDrug Interactionsen
dc.subjectGraft Rejectionen
dc.subjectGraft Survivalen
dc.subjectHeptanoic Acids/pharmacology/therapeutic useen
dc.subjectHomocysteine/blooden
dc.subjectHumansen
dc.subjectHyperlipidemias/*complications/drug therapyen
dc.subjectHypolipidemic Agents/*pharmacology/therapeutic useen
dc.subjectImmunosuppressive Agents/pharmacologyen
dc.subjectKidney/*drug effectsen
dc.subjectKidney Diseases/*complications/drug therapyen
dc.subjectKidney Function Testsen
dc.subjectKidney Transplantationen
dc.subjectMultivariate Analysisen
dc.subjectPeripheral Vascular Diseases/drug therapyen
dc.subjectPlacebosen
dc.subjectPyrroles/pharmacology/therapeutic useen
dc.subjectRandomized Controlled Trials as Topicen
dc.subjectRenal Artery Obstruction/complicationsen
dc.subjectRenal Circulationen
dc.subjectRenal Dialysisen
dc.subjectRisk Factorsen
dc.subjectSimvastatin/pharmacology/therapeutic useen
dc.subjectSwineen
dc.subjectTacrolimus/pharmacology/therapeutic useen
dc.titleStatins and renal functionen
heal.abstractRenal disease is often associated with an increased risk of vascular events. Moreover, an accelerated form of atherosclerosis commonly occurs in these patients. The reasons for these associations are not clearly defined but include the widespread presence of several established risk factors (eg, dyslipidemia, hypertension, and diabetes). Other predictors of atherosclerotic disease may also be abnormally elevated (eg, homocysteine, fibrinogen, and lipoprotein a). In addition, there is evidence that impaired renal function per se predicts vascular risk. Despite this high-risk background, the potential benefit of treatment with statins has not been widely investigated in these patients. The present review considers the evidence (experimental and clinical) that statins exert beneficial effects in patients with different types of renal disease. This includes improved renal function, decreased microalbuminuria, and a fall in blood pressure. Statins may also improve renal allograft survival. The potential mechanisms mediating these effects are considered. The interactions between statins and several risk factors that may be present in patients with impaired renal function are also considered. There is an urgent need to define the role of statins in these high-risk patients. Which is the statin of choice? This question is relevant because impaired renal function can interfere with statin pharmacokinetics. Furthermore, other drugs administered to these patients may cause serious interactions with statins.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12365855-
heal.identifier.secondaryhttp://ang.sagepub.com/content/53/5/493.full.pdf-
heal.journalNameAngiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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