Local effects of recombinant rat interleukin-6 on the peripheral nervous system
| dc.contributor.author | Deretzi, G. | en |
| dc.contributor.author | Pelidou, S. H. | en |
| dc.contributor.author | Zou, L. P. | en |
| dc.contributor.author | Quiding, C. | en |
| dc.contributor.author | Zhu, J. | en |
| dc.date.accessioned | 2015-11-24T19:06:38Z | |
| dc.date.available | 2015-11-24T19:06:38Z | |
| dc.identifier.issn | 0019-2805 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20361 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Demyelinating Diseases/immunology/pathology | en |
| dc.subject | Histocompatibility Antigens Class II/analysis | en |
| dc.subject | Interleukin-6/immunology/*toxicity | en |
| dc.subject | Macrophages/immunology | en |
| dc.subject | Male | en |
| dc.subject | Neuritis/immunology/pathology | en |
| dc.subject | Peripheral Nervous System Diseases/*immunology/pathology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Lew | en |
| dc.subject | Recombinant Proteins/immunology/toxicity | en |
| dc.subject | Sciatic Nerve/immunology | en |
| dc.subject | T-Lymphocyte Subsets/immunology | en |
| dc.title | Local effects of recombinant rat interleukin-6 on the peripheral nervous system | en |
| heal.abstract | Interleukin-6 (IL-6) is a multifunctional cytokine with a broad range of activities and can affect a variety of target cells or systems in multiple ways. However, there is currently no consensus on how IL-6 directly affects the peripheral nervous tissue. We performed histopathological and immunohistochemical analyses to investigate the direct effects of recombinant rat IL-6 (rrIL-6) following its intraneural injection into the sciatic nerve of adult Lewis rats. One day after injection, a large number of macrophages, major histocompatibility complex (MHC) class II positive cells, and CD4+ and CD8+ T cells appeared within the perineurium and endoneurium. From day 4 to day 7 after injection, we observed a gradual increase of inflammation and demyelination. On day 7, demyelination affected more than 80% of nerve fibres. In contrast, in the sterile phosphate-buffered saline (PBS)-injected control group, lower inflammation and fewer demyelinating nerve fibres were observed on days 4 and 7. Thus, intraneural injection of rrIL-6 into the sciatic nerve induces high inflammation and severe demyelination. This study improves our understanding of the effector mechanisms underlying inflammation and demyelination and identifies IL-6 as an essential mediator of inflammation and demyelination in the peripheral nervous system after local administration. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/10457210 | - |
| heal.journalName | Immunology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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