Epstein-Barr virus in non-Hodgkin's lymphomas of the upper respiratory tract: association with sinonasal localization and expression of NK and/or T-cell antigens by tumour cells
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kanavaros, P.
Briere, J.
Lescs, M. C.
Gaulard, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Pathol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Fifty-five cases of non-Hodgkin's lymphoma (NHL) of the upper respiratory tract, comprising 27 sinonasal (SN) and 28 Waldeyer's ring (WR) NHL, were investigated for expression of Epstein-Barr virus (EBV)-encoded EBER transcripts and latent membrane protein-1 (LMP-1) by RNA in-situ hybridization (RISH) and immunohistochemistry, respectively. Thirty-two cases were B-cell tumours (10 SNHLs and 22 WRNHLs) and 23 cases expressed natural killer (NK) and/or T-cell antigens (17 SNHLs and 6 WRNHLs). EBER transcripts were detected in tumour cells in 19 lymphomas expressing NK and/or T-cell antigens (16/17 SHNHLs and 3/6 WRNHLs) but in only 2/32 B-NHLs (1/10 SNHLs and 1/22 WRNHLs). LMP-1 expression was found in tumour cells in the 19 EBER-positive tumours expressing NK and/or T-cell antigens but in none of the B-cell lymphomas. All the LMP-1-positive lymphomas expressed the CD30 molecule in tumour cells. These results indicate that in lymphomas of the upper respiratory tract, EBV is strongly associated with sinonasal localization and expression of NK and/or T-cell antigens by tumour cells. EBV can also be detected in some cases of WRNHLs expressing NK and/or T-cell antigens, whereas it is rarely found in B-cell SNHLs and WRNHLs. Furthermore, the detection of the LMP-1 protein in tumour cells in most SNHLs and some WRNHLs expressing NK and/or T-cell antigens, in view of the LMP-1 transforming potential, suggests that EBV may play a role in the pathogenesis of these lymphomas.
Περιγραφή
Λέξεις-κλειδιά
Antigens, Differentiation, T-Lymphocyte/immunology, Herpesvirus 4, Human/genetics/immunology/*isolation & purification, Humans, Immunoenzyme Techniques, Immunophenotyping, In Situ Hybridization, Killer Cells, Natural/immunology, Lymphoma, Non-Hodgkin/immunology/*virology, Paranasal Sinus Neoplasms/immunology/*virology, RNA, Messenger/analysis, RNA, Viral/analysis, T-Lymphocytes/immunology, Tonsillar Neoplasms/immunology/*virology, Viral Matrix Proteins/analysis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8778335
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-9896(199603)178:3<297::AID-PATH469>3.0.CO;2-E/asset/469_ftp.pdf?v=1&t=h0exc9l1&s=b7a2d83d218cbe7abf184c76942756463e82add1
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1096-9896(199603)178:3<297::AID-PATH469>3.0.CO;2-E/asset/469_ftp.pdf?v=1&t=h0exc9l1&s=b7a2d83d218cbe7abf184c76942756463e82add1
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής