Free functional muscle transfer failure and thrombophilic gene mutations as a potential risk factor: a case report
Φόρτωση...
Ημερομηνία
Συγγραφείς
Vekris, M. D.
Ovrenovits, M.
Dova, L.
Beris, A. E.
Soucacos, P. N.
Kolaitis, N.
Vartholomatos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Microsurgery
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The evolution of microsurgery popularized the free functioning muscle transfers as secondary procedures to reanimate paralyzed extremities after severance of the brachial plexus, especially when the surgeon deals with late cases. Studies considering transplantation, describe thrombophilic factors as a cause of severe complications after transplantation, such as acute or early rejection episodes, delayed graft function, or chronic graft dysfunction. It is the first time that thrombophilia associated with free muscle-graft rejection is reported. A young man who had two free functional muscle transfers for brachial plexus reconstruction in the same forearm within an interval of 6 months. The free functional muscle transfer was failed in both cases because of vein thrombosis and subsequent arterial clot. The possibility of thrombophilia was investigated and during the genetic investigation it was discovered that he was heterozygous for the mutations of factor V, G1691A-Leiden, A4070G and homozygous for the MTHFR C677T mutation.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Brachial Plexus/*injuries, Factor V/genetics, Forearm Injuries/surgery, Genetic Markers/genetics, Graft Survival, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2)/genetics, Muscle, Skeletal/*transplantation, Mutation/*genetics, Postoperative Complications, Surgical Flaps/*blood supply, Thromboembolism/genetics, Thrombophilia/complications/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17295258
http://onlinelibrary.wiley.com/store/10.1002/micr.20312/asset/20312_ftp.pdf?v=1&t=h0mcz3yg&s=664273cdaba54c47c4d7a1a0a57acf9a9e3c5acf
http://onlinelibrary.wiley.com/store/10.1002/micr.20312/asset/20312_ftp.pdf?v=1&t=h0mcz3yg&s=664273cdaba54c47c4d7a1a0a57acf9a9e3c5acf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής