Complete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinant

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dc.contributor.authorDedepsidis, E.en
dc.contributor.authorPliaka, V.en
dc.contributor.authorKyriakopoulou, Z.en
dc.contributor.authorBrakoulias, C.en
dc.contributor.authorLevidiotou-Stefanou, S.en
dc.contributor.authorPratti, A.en
dc.contributor.authorMamuris, Z.en
dc.contributor.authorMarkoulatos, P.en
dc.date.accessioned2015-11-24T19:28:12Z
dc.date.available2015-11-24T19:28:12Z
dc.identifier.issn0928-8244-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22879
dc.rightsDefault Licence-
dc.subjectAntigens, Viral/analysis/geneticsen
dc.subjectCapsid Proteins/analysis/chemistry/*geneticsen
dc.subjectChilden
dc.subjectFeces/virologyen
dc.subject*Genome, Viralen
dc.subjectHumansen
dc.subjectPoliovirus/chemistry/*geneticsen
dc.subjectPoliovirus Vaccine, Oral/*genetics/immunology/metabolismen
dc.subjectRecombinant Proteins/geneticsen
dc.subject*Recombination, Geneticen
dc.titleComplete genomic characterization of an intertypic Sabin 3/Sabin 2 capsid recombinanten
heal.abstractThe genetic properties of strain K/2002, isolated from fecal samples of a 7-month-old child who had received his first oral poliovirus vaccine (OPV) dose at the age of 3 months, are described. Preliminary sequencing characterization of isolate K/2002 revealed an S3/S2 recombination event at the 3' end of the VP1 coding region. A recombination event resulted in the introduction of six Sabin 2 amino acid residues in a Sabin 3 genomic background. Furthermore, mutations associated with loss of the attenuated phenotype of Sabin 3 strains have been identified in the genome of isolate K/2002. The data presented here emphasize the need for careful planning of vaccination strategies, which involve stopping OPV administration in regions that are certified to be polio-free.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1574-695X.2008.00381.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18328076-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1574-695X.2008.00381.x/asset/j.1574-695X.2008.00381.x.pdf?v=1&t=h09fvkwt&s=c211b2d1977fa389cbbabcd76551f84417503860-
heal.journalNameFEMS Immunol Med Microbiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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