Anti-Inflammatory, Antiproliferative, and Radical-Scavenging Activities of Tolfenamic Acid and Its Metal Complexes
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Hadjipavlou-Litina, D. | en |
| dc.contributor.author | Primikiri, A. | en |
| dc.contributor.author | Staninska, M. | en |
| dc.contributor.author | Kotoglou, C. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.date.accessioned | 2015-11-24T16:51:31Z | |
| dc.date.available | 2015-11-24T16:51:31Z | |
| dc.identifier.issn | 1612-1872 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9743 | |
| dc.rights | Default Licence | - |
| dc.subject | copper(ii) complexes | en |
| dc.subject | crystal-structure | en |
| dc.subject | diclofenac | en |
| dc.subject | derivatives | en |
| dc.subject | drugs | en |
| dc.subject | assay | en |
| dc.title | Anti-Inflammatory, Antiproliferative, and Radical-Scavenging Activities of Tolfenamic Acid and Its Metal Complexes | en |
| heal.abstract | Some new complexes of tolfenamic acid (=2-[(2-methyl-3-chlorophenyl)amino]benzoic acid; Htolf) with potentially interesting biological activities are described. The complexes [Mn(tolf)(2)(H(2)O)(2)], [Co(tolf)(2)(H(2)O)(2)], [Ni(tolf(2)(H(2)O)(2)], [CU(tolf)(2)(H(2)O)](2), and [Zn(tolf)(2)(H(2)O)] were prepared by the reaction of tolfenamic acid, a potent anti-inflammatory drug, with metal salts. The radical-scavenging activities of the complexes were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging assay. Their ability to inhibit soybean lipoxygenase, beta-glucuronidase, and trypsin-induced proteolysis wits studied. Their inhibitory effects on rat paw edema induced by carrageenin was studied and compared with those of tolfenamic acid. The complex [Zn(tolf)(2)(H(2)O)] exhibited the strongest in vivo inhibitory effect at 0.1 mm/kg Body Weight (BW: 93.0 +/- 0.9%). superior than the inhibition induced by tolfenamic acid at the same molar dose (76.0 +/- 0.9%). Tolfenamic acid and its metal complexes have been evaluated for antiproliferative activity in vitro against the cells of three human cancer cell lines. MCF-7 (breast cancer cell line), T24 (bladder cancer cell line), and A-549 (non-small cell lung carcinoma), and a mouse fibroblast L-929 cell line. The complexes [Mn(tolf)(2)(H(2)O)(2)] and [Cu-(tolf)(2)(H(2)O)](2) have shown selectivity against T24 cell line. The IC(50) values of these two complexes against T24 cancer cell lines are in a micromolar range similar or better to that of the antitumor drug cisplatin. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000267784200017 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/cbdv.200800120/asset/948_ftp.pdf?v=1&t=h0dut24e&s=558cba456a8d5efdee97643aff683361b6ab257b | - |
| heal.journalName | Chemistry & Biodiversity | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2009 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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