Synthesis, structural characterization and in vitro cytotoxicity of new Au(III) and Au(I) complexes with thioamides
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kouroulis, K. N.
Hadjikakou, S. K.
Kourkoumelis, N.
Kubicki, M.
Male, L.
Hursthouse, M.
Skoulika, S.
Metsios, A. K.
Tyurin, V. Y.
Dolganov, A. V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Royal Society of Chemistry
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Dalton Transactions
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The reactions of tetrachloroauric(III) acid (HAuCl(4)) with the thioamides; 2-mercapto-benzothiazole (mbztH) and 5-ethoxy-2-mercapto-benzimidazole (EtmbzimH) lead to the desulfuration of the ligands and the formation of the ionic complexes {[AuCl(4)](-)[bztH(2)](+)} (1), and {[AuCl(4)](-)[EtbzimH(2)](+)(H(2)O)} (2) (where bztH(2)(+) and EtbzimH(2)(+) are the desulfurated cations of the starting ligands). The reaction of HAuCl(4) with 2-mercapto-nicotinic acid (mnaH(2)), however results in the formation of 2-sulfonate-nicotininc acid (C(6)H(5)NO(5)S) (3) with the simultaneous oxidation of the sulfur atom. On the other hand, the reactions of the gold(I) complex [Au(tpp)Cl] (4) (tpp = triphenylphosphine (Ph(3)P)) with the thioamides; 2-mercapto-thiazolidine (mtzdH), 2-mercapto-benzothiazole (mbztH) and 5-chloro-2-mercapto-benzothiazole (ClmbztH) in the presence of potassium hydroxide resulted in the formation of the gold(I) complexes of formulae [Au(tpp)(mtzd)] (5), [Au(tpp)(mbzt)] (6) and [Au(tpp)(Clmbzt)] (7) without ligand desulfuration. All complexes have been characterized by elemental analysis, FT-IR, far-FT-IR, (1)H-NMR, spectroscopic techniques and X-Ray crystallography. The electrochemical behavior of 1, 2 and 4-7 complexes and the ligands EtmbzimH, mbztH and mnaH(2) was also studied in acetonitrile and DMF using cyclic voltammetry. The results are in support of a mechanism of desulfuration of the ligands by Au(III), involving a first oxidation of S to -SO(3)(-), followed by a C-S bond cleavage. This is also supported by PM6 calculations of bond dissociation energies of the various compounds involved. Complexes 1, 2 and 4-7 were tested for in vitro cytotoxicity against leiomyosarcoma cells and the results are discussed in relation with the geometry of the complexes and compared with those of cisplatin and other metals. Complexes 1 and 5 showed higher activity than that of cisplatin, while HAuCl(4) was inactive against sarcoma cells.
Περιγραφή
Λέξεις-κλειδιά
crystal-structure, heterocyclic thioamides, antimony(iii) complexes, organotin(iv) complexes, diiodine adducts, ionic liquids, ligands, benzimidazole-2-thione, derivatives, silver(i)
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000272193900009
http://pubs.rsc.org/en/content/articlepdf/2009/dt/b909587j
http://pubs.rsc.org/en/content/articlepdf/2009/dt/b909587j
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας