Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase
| dc.contributor.author | Dentan, C. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Chapman, M. J. | en |
| dc.contributor.author | Ninio, E. | en |
| dc.date.accessioned | 2015-11-24T16:44:07Z | |
| dc.date.available | 2015-11-24T16:44:07Z | |
| dc.identifier.issn | 0005-2760 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8773 | |
| dc.rights | Default Licence | - |
| dc.subject | paf | en |
| dc.subject | acetylhydrolase | en |
| dc.subject | pefabloc | en |
| dc.subject | inflammatory mediator | en |
| dc.subject | lipoprotein | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | human-plasma | en |
| dc.subject | human-serum | en |
| dc.subject | macrophages | en |
| dc.subject | acether | en |
| dc.subject | lipoproteins | en |
| dc.subject | degradation | en |
| dc.title | Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase | en |
| heal.abstract | We report here that 4-[2-aminoethyl]benzenesulfonyl fluoride (Pefabloc SC, Pefabloc), a new irreversible serine proteinase inhibitor, efficiently inhibits both human and rat platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase). Indeed, low concentrations of Pefabloc (0.1 mM) rapidly and totally inactivate both human plasma-, VLDL-, IDL-, LDL- and HDL-associated acetylhydrolase, and in addition, acetylhydrolase synthesized and released by human adherent monocytes in culture, as well as rat brain cytosolic acetylhydrolase. By contrast, Pefabloc only minimally inhibited the phospholipase A(2) (PLA(2)) activity from Naja naja and from porcine pancreas. In addition, Pefabloc is relatively nontoxic, stable and convenient to use. Henceforth, Pefabloc may replace both DFP and PMSF and therefore constitutes a useful and valuable tool in future studies of acetylhydrolase. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://A1996TX50200010 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/000527609500226X/1-s2.0-000527609500226X-main.pdf?_tid=a32f72c63742466c77d9338f80cc0519&acdnat=1333111086_d9dab053d1010dc71ca18d6c0a84cd6d | - |
| heal.journalName | Biochimica Et Biophysica Acta-Lipids and Lipid Metabolism | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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