Pre-inflammatory Mediators and Lymphocyte Subpopulations in Preterm Neonates with Sepsis
| dc.contributor.author | Hotoura, E. | en |
| dc.contributor.author | Giapros, V. | en |
| dc.contributor.author | Kostoula, A. | en |
| dc.contributor.author | Spyrou, P. | en |
| dc.contributor.author | Andronikou, S. | en |
| dc.date.accessioned | 2015-11-24T18:57:10Z | |
| dc.date.available | 2015-11-24T18:57:10Z | |
| dc.identifier.issn | 1573-2576 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19139 | |
| dc.rights | Default Licence | - |
| dc.title | Pre-inflammatory Mediators and Lymphocyte Subpopulations in Preterm Neonates with Sepsis | en |
| heal.abstract | The aim of this study is to investigate prospectively specific immune system factors in preterm neonates with late-onset sepsis and infection-free controls. Matched preterm neonates (n = 82) were divided into three groups: suspected infection (n = 25), sepsis (n = 17), and infection-free controls (n = 40). Serial measurements were made of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), lymphocyte subsets [CD3+, CD4+, CD8+, natural killer (NK) cells, and B cells], the immunoglobulins (IgG, IgM, and IgA), C-reactive protein (CRP), and the total blood count, before, 2 days after initiation of treatment, and after stopping treatment. The percentages of NK and B cells were higher in the sepsis group, but those of CD3+, CD4+, and CD8+ showed no differences. IgG was lower in the sepsis group. IL-6 >30 pg/ml and TNF-alpha >30 pg/ml were sensitive sepsis predictors with sensitivity 1 (0.78-1) and 1 (0.79-1), respectively, but their specificity was poor. CRP was a specific [0.90 (0.80-0.96)] but not sensitive index [0.68 (0.48-0.85)], and its combination with IL-6 or TNF-alpha could enhance their diagnostic accuracy. It is concluded that NK and B cells may be elevated in late neonatal sepsis. IL-6 or TNF-alpha combined with CRP is a good diagnostic marker for late-onset sepsis in preterm neonates. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s10753-011-9416-3 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22160841 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/p5w688v5wl888037/fulltext.pdf | - |
| heal.journalName | Inflammation | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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