The anti-platelet approach targeting the fibrinogen ligand of the GPIIb/IIIa receptor
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Peptide Science
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Activation of the platelet surface receptor GPIib/IIIa is the final pathway of platelet aggregation, regardless of the initiating stimulus. RGD analogues, peptidomimetics and monoclonal antibodies to GPIib/IIIa have been developed targeting the blockage of the receptor and inhibition of the fibrinogen binding. However, the intrinsic activating effect of GPIIb/IIIa blockers is widely discussed as one potential contributing factor for the disappointing outcome of trials with GPIIb/IIIa inhibitors. An alternative method for thrombus prevention could be the use of specific fibrinogen blockers since they will act at the final step of the platelet aggregation and are expected to leave the receptor unaffected. To achieve this target the design of the fibrinogen ligands could be based on (i) sequences derived from GPIIb/IIIa ligand binding sites, and (ii) sequences complementary to RGD and/or to fibrinogen gamma-chain. The available information, which could be used as a starting point for developing potent fibrinogen ligands, is reviewed. Copyright (C) 2004 European Peptide Society and John Wiley Sons, Ltd.
Περιγραφή
Λέξεις-κλειδιά
alpha(iib)beta(3) receptor, fibrinogen blockers, gpilb/lila binding domains, integrin inhibitors, platelet aggregation inhibitors, glycoprotein-iib-iiia, platelet integrin gpiib/iiia, monoclonal-antibody epitopes, rgd-containing peptides, amino-acid-sequence, asp-binding domain, a-alpha-chain, glanzmann thrombasthenia, iib/iiia antagonists, beta(3) subunit
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000224655900001
http://onlinelibrary.wiley.com/store/10.1002/psc.603/asset/603_ftp.pdf?v=1&t=h0f8tzzb&s=a299bba9b484c14fd3f7df6d6376dc97049bc835
http://onlinelibrary.wiley.com/store/10.1002/psc.603/asset/603_ftp.pdf?v=1&t=h0f8tzzb&s=a299bba9b484c14fd3f7df6d6376dc97049bc835
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας