Correlation between dynamic MRI and outcome in patients with malignant gliomas

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dc.contributor.authorWong, E. T.en
dc.contributor.authorJackson, E. F.en
dc.contributor.authorHess, K. R.en
dc.contributor.authorSchomer, D. F.en
dc.contributor.authorHazle, J. D.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorJaeckle, K. A.en
dc.contributor.authorYung, W. K.en
dc.contributor.authorLevin, V. A.en
dc.contributor.authorLeeds, N. E.en
dc.date.accessioned2015-11-24T19:26:56Z
dc.date.available2015-11-24T19:26:56Z
dc.identifier.issn0028-3878-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22768
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBrain Neoplasms/*diagnosis/metabolism/pathologyen
dc.subjectContrast Media/pharmacokineticsen
dc.subjectGadolinium DTPA/diagnostic use/pharmacokineticsen
dc.subjectGlioblastoma/*diagnosis/metabolism/pathologyen
dc.subjectHumansen
dc.subject*Magnetic Resonance Imagingen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectRetrospective Studiesen
dc.subjectSurvival Analysisen
dc.subjectTime Factorsen
dc.titleCorrelation between dynamic MRI and outcome in patients with malignant gliomasen
heal.abstractWe assessed the correlation between dynamic MRI results and clinical outcomes in patients with malignant gliomas. Rapid serial MRIs were obtained after bolus injection of gadolinium that resulted in an initial fast uptake followed by a slow uptake of contrast. The maximum rate of uptake and delayed rate of uptake were correlated with survival and prognostic covariates such as age and histology. In 121 subjects, higher maximum uptake rates, 3.6 signal intensity units per second or greater, were associated with shorter survival (p = 0.0066). The correlation of delayed rate of uptake with survival was less significant. After adjusting for age, histology, and Karnofsky performance score, the maximum rate of uptake remained more significantly correlated with survival than the delayed rate of uptake. Thirty-one patients had surgery within 1 month of dynamic MRI, and those with glioblastoma multiforme or anaplastic gliomas had higher maximum rates of uptake than those with pure necrosis or mixed tumor and necrosis (p = 0.022). No correlation between delayed rate of uptake and histology was seen in this group of patients. Our results suggest that the maximum rate of uptake in dynamic MRI can be a prognostic measure for patients with malignant gliomas. Further prospective study is needed to assess the utility of this technique for evaluating brain tumors.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9521274-
heal.journalNameNeurologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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