alpha-Mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surface
| dc.contributor.author | Belmonte, S. A. | en |
| dc.contributor.author | Challa, A. | en |
| dc.contributor.author | Gutierrez, L. S. | en |
| dc.contributor.author | Bertini, F. | en |
| dc.contributor.author | Sosa, M. A. | en |
| dc.date.accessioned | 2015-11-24T19:36:59Z | |
| dc.date.available | 2015-11-24T19:36:59Z | |
| dc.identifier.issn | 0105-6263 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23972 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Body Fluids/enzymology | en |
| dc.subject | Epididymis/enzymology | en |
| dc.subject | Hydrogen-Ion Concentration | en |
| dc.subject | Ligands | en |
| dc.subject | Male | en |
| dc.subject | Mannosidases/*metabolism | en |
| dc.subject | Rats | en |
| dc.subject | Receptors, Cytoplasmic and Nuclear/*metabolism | en |
| dc.subject | Spermatozoa/*metabolism | en |
| dc.subject | alpha-Mannosidase | en |
| dc.title | alpha-Mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surface | en |
| heal.abstract | This study demonstrates that alpha-mannosidase from rat epididymal fluid is a ligand for phosphomannosyl receptors on the sperm surface. This enzyme was bound to intact epididymal spermatozoa with high affinity and in saturable form, and the binding was inhibited by mannose-6-phosphate but not by phosphorylated derivatives of fructose. Treatment of the enzyme with sodium periodate inhibited the binding of alpha-mannosidase, confirming that a carbohydrate residue is involved in the interaction with spermatozoa. Evidence is also presented that the cation-independent phosphomannosyl receptors are responsible for the interaction with alpha-mannosidase. These findings suggest a new role for extracellular transport mediated by the mannose-6-phosphate receptor. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/9805243 | - |
| heal.journalName | Int J Androl | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1998 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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