The local component of the acute cardiovascular response to simulated apneas in brain-dead humans
| dc.contributor.author | Lahana, A. | en |
| dc.contributor.author | Costantopoulos, S. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.date.accessioned | 2015-11-24T19:38:05Z | |
| dc.date.available | 2015-11-24T19:38:05Z | |
| dc.identifier.issn | 0012-3692 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24109 | |
| dc.rights | Default Licence | - |
| dc.subject | Anoxia | en |
| dc.subject | Brain Death/*physiopathology | en |
| dc.subject | Cardiovascular System/*physiopathology | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Hypercapnia | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Sleep Apnea, Central/*physiopathology | en |
| dc.title | The local component of the acute cardiovascular response to simulated apneas in brain-dead humans | en |
| heal.abstract | STUDY OBJECTIVES: To investigate the local cardiovascular response to hypoxemia and hypercapnia in a simulated central apnea model in which the central autonomic regulation was absent. DESIGN: Experimental study. SETTING: A university hospital. INTERVENTIONS: A simulated central apnea model achieved by a particular setting of the mechanical ventilator in 10 brain-dead patients. MEASUREMENTS: Hemodynamic studies using right-heart catheterization and continuous monitoring of arterial blood gas levels. RESULTS: Hypercapnic hypoxic apneas were associated with no change in heart rate, fall in mean systemic arterial pressure and systemic vascular resistance (from 83 +/- 9 to 68 +/- 7 mm Hg and 1,115 +/- 82 to 768 +/- 58 dyne.s.cm(-5), respectively; each p < 0.05), and rise in mean pulmonary artery pressure, pulmonary vascular resistance, and pulmonary capillary wedge pressure (PCWP) [from 17 +/- 1.5 to 26 +/- 3 mm Hg, 102 +/- 27 to 166 +/- 43 dyne.s.cm(-5), and 10 +/- 1 to 14 +/- 2 mm Hg, respectively; each p < 0.05]. CONCLUSION: Our results suggest that in the absence of central autonomic regulation in humans, apnea-induced hypoxemia and/or hypercapnia are associated with peripheral vasodilatation and pulmonary vasoconstriction, which are probably local in origin, as well as a significant increase in PCWP indicating cardiac dysfunction. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1378/chest.128.2.634 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/16100148 | - |
| heal.identifier.secondary | http://chestjournal.chestpubs.org/content/128/2/634.full.pdf | - |
| heal.journalName | Chest | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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