Desferrioxamine attenuates minor lung injury following surgical acute liver failure
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kostopanagiotou, G. G.
Kalimeris, K. A.
Arkadopoulos, N.
Pafiti, A.
Panagopoulos, D.
Smyrniotis, V.
Vlahakos, D.
Routsi, C.
Lekka, M. E.
Nakos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
European Respiratory Society: ERJ
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
European Respiratory Journal
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Acute liver failure (ALF) can be complicated by lung dysfunction. The aim of this study was to test the hypothesis that inhibition of oxidative stress through iron chelation with desferrioxamine (DFX) attenuates pulmonary injury caused by ALF. 14 adult female domestic pigs were subjected to surgical devascularisation of the liver and were randomised to a study group (DFX group, n=7), which received post-operative intravenous infusion of DFX (14.5 mg.kg(-1).h(-1) for the first 6 h post-operatively and 2.4 mg.kg(-1).h(-1) until completion of 24 h), and a control group (n=7). Post-operative lung damage was evaluated by histological and bronchoalveolar lavage fluid (BALF) analysis. DFX resulted in reduced BALF protein levels and tissue phospholipase (PL)A(2) activity. Plasma malondlaidehyde and BALF nitrate and nitrite concentrations were lower, while catalase activity in the lung was higher after DFX treatment. PLA(2), Platelet-activating factor acetylhydrolase and total cell counts in BALF did not differ between groups. Histological examination revealed reduced alveolar collapse, pneumonocyte necrosis and total lung injury in the DFX-treated animals. DFX reduced systemic and pulmonary oxidative stress during ALF. The limited activity of PLA(2) and the attenuation of pneumonocyte necrosis could represent beneficial mechanisms by which DFX improves alveolar-capillary membrane permeability and prevents alveolar space collapse.
Περιγραφή
Λέξεις-κλειδιά
alveolocapillary permeability, antioxidants, iron regulation, liver-lung interactions, lung injury, oxidants, respiratory-distress-syndrome, fulminant hepatic-failure, bronchoalveolar lavage fluid, oxidative stress, phospholipase a(2), pulmonary-edema, iron, transplantation, deferoxamine, proteins
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000267301800026
http://erj.ersjournals.com/content/33/6/1429.full.pdf
http://erj.ersjournals.com/content/33/6/1429.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας