The role of the PTEN gene in malignant gliomas

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dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorVoulgaris, S.en
dc.date.accessioned2015-11-24T19:26:18Z
dc.date.available2015-11-24T19:26:18Z
dc.identifier.issn0028-3843-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22709
dc.rightsDefault Licence-
dc.subjectActive Transport, Cell Nucleusen
dc.subjectAnimalsen
dc.subjectBrain Neoplasms/*geneticsen
dc.subjectCell Nucleus/metabolismen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectGlioma/*geneticsen
dc.subjectHumansen
dc.subjectPTEN Phosphohydrolase/*geneticsen
dc.subjectSignal Transduction/geneticsen
dc.titleThe role of the PTEN gene in malignant gliomasen
heal.abstractThis article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20358487-
heal.journalNameNeurol Neurochir Polen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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