Estrogen receptor beta (ERbeta) expression in breast carcinomas is not correlated with estrogen receptor alpha (ERalpha) and prognosis: the Greek experience

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dc.contributor.authorStefanou, D.en
dc.contributor.authorBatistatou, A.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:18:08Z
dc.date.available2015-11-24T19:18:08Z
dc.identifier.issn0392-2936-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21845
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBiopsy, Needleen
dc.subjectBreast Neoplasms/genetics/*mortality/*pathologyen
dc.subjectCohort Studiesen
dc.subjectEstrogen Receptor alphaen
dc.subjectEstrogen Receptor betaen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectProbabilityen
dc.subjectPrognosisen
dc.subjectReceptors, Estrogen/*analysis/geneticsen
dc.subjectRisk Assessmenten
dc.subjectSensitivity and Specificityen
dc.subjectStatistics, Nonparametricen
dc.subjectSurvival Rateen
dc.subjectTumor Markers, Biological/*analysisen
dc.titleEstrogen receptor beta (ERbeta) expression in breast carcinomas is not correlated with estrogen receptor alpha (ERalpha) and prognosis: the Greek experienceen
heal.abstractEstrogen receptors (ER) are members of the nuclear receptor superfamily of ligand-activated transcription factors and mediate the effects of estrogen on target tissues. ERalpha was the first estrogen receptor to be characterized, and ERbeta was identified ten years later. The role of ERbeta in breast cancer pathobiology is largely unknown because specific antibodies have not been available until recently. The purpose of this study was to explore the expression of ERbeta in breast neoplasms and to correlate it with ERalpha and prognosis. ERa and ERbeta expression was monitored immunohistochemically in 59 breast carcinomas. We found no correlation between ERalpha and ERbeta expression, between ERbeta expression and the known prognostic indicators such as tumor size, grade or lymph node status, or between ERbeta expression and survival. Our findings contribute to the better understanding of the role of ERbeta in breast cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15285303-
heal.journalNameEur J Gynaecol Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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