Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials
| dc.contributor.author | Balk, E. M. | en |
| dc.contributor.author | Bonis, P. A. | en |
| dc.contributor.author | Moskowitz, H. | en |
| dc.contributor.author | Schmid, C. H. | en |
| dc.contributor.author | Ioannidis, J. P. | en |
| dc.contributor.author | Wang, C. | en |
| dc.contributor.author | Lau, J. | en |
| dc.date.accessioned | 2015-11-24T19:26:41Z | |
| dc.date.available | 2015-11-24T19:26:41Z | |
| dc.identifier.issn | 0098-7484 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22751 | |
| dc.rights | Default Licence | - |
| dc.subject | *Data Interpretation, Statistical | en |
| dc.subject | *Meta-Analysis as Topic | en |
| dc.subject | Quality Control | en |
| dc.subject | Randomized Controlled Trials as Topic/*standards/statistics & numerical data | en |
| dc.subject | Research Design | en |
| dc.subject | *Treatment Outcome | en |
| dc.title | Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials | en |
| heal.abstract | CONTEXT: Specific features of trial quality may be associated with exaggeration or shrinking of the observed treatment effect in randomized studies. Therefore, assessment of trial quality is often used in meta-analysis. However, the degree to which specific quality measures are associated with treatment effects has not been well established across a broad range of clinical areas. OBJECTIVE: To determine if quality measures are associated with treatment effect size in randomized controlled trials (RCTs). DESIGN: Quality measures from published quality assessment scales were evaluated in RCTs included in meta-analyses from 4 medical areas (cardiovascular disease, infectious disease, pediatrics, and surgery). Included meta-analyses incorporated at least 6 RCTs, examined dichotomous outcomes, and demonstrated significant between-study heterogeneity in the odds ratio (OR) scale. MAIN OUTCOME MEASURES: Relative ORs comparing overall treatment effect (summary OR) of high vs low-quality studies, as determined by each quality measure, with relative ORs less than 1 indicating larger treatment effect in low-quality studies. RESULTS: Twenty-four quality measures were analyzed for 276 RCTs from 26 meta-analyses. Relative ORs of high vs low-quality studies for these quality measures ranged from 0.83 to 1.26; none was statistically significantly associated with treatment effect. The proportion of studies fulfilling specific quality measures varied widely in the 4 medical areas. In analyses limited to specific medical areas, placebo control, multicenter studies, study country, caregiver blinding, and statistical methods were significantly associated with treatment effect on 7 occasions. These relative ORs ranged from 0.40 to 1.74. However, the directions of these associations were not consistent. CONCLUSIONS: Individual quality measures are not reliably associated with the strength of treatment effect across studies and medical areas. Although use of specific quality measures may be appropriate in specific well-defined areas in which there is pertinent evidence, findings of associations with treatment effect cannot be generalized to all clinical areas or meta-analyses. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/12052127 | - |
| heal.journalName | JAMA | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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