Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation
| dc.contributor.author | Lazaros, L. A. | en |
| dc.contributor.author | Hatzi, E. G. | en |
| dc.contributor.author | Xita, N. V. | en |
| dc.contributor.author | Makrydimas, G. V. | en |
| dc.contributor.author | Kaponis, A. I. | en |
| dc.contributor.author | Takenaka, A. | en |
| dc.contributor.author | Kosmas, I. P. | en |
| dc.contributor.author | Sofikitis, N. V. | en |
| dc.contributor.author | Stefos, T. I. | en |
| dc.contributor.author | Zikopoulos, K. A. | en |
| dc.contributor.author | Georgiou, I. A. | en |
| dc.date.accessioned | 2015-11-24T19:35:36Z | |
| dc.date.available | 2015-11-24T19:35:36Z | |
| dc.identifier.issn | 1573-7330 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23718 | |
| dc.rights | Default Licence | - |
| dc.title | Aromatase (CYP19) gene variants influence ovarian response to standard gonadotrophin stimulation | en |
| heal.abstract | PURPOSE: The association of cytochrome P450 aromatase gene CYP19(TTTA) ( n ) polymorphism with ovarian response to FSH stimulation was explored. METHODS: Three hundred women undergoing medically assisted reproduction and 300 women with at least one spontaneous pregnancy participated in the study. CYP19(TTTA) ( n ) polymorphism was genotyped, while serum hormones were determined. During oocyte retrieval, the follicular size, the follicle and oocyte numbers were recorded. RESULTS: Six CYP19(TTTA) ( n ) alleles with 7 to 12 repeats were revealed. Women homozygous for long CYP19(TTTA) ( n ) alleles presented with lower serum FSH levels at the third day of the menstrual cycle (p < 0.001) and higher large follicle numbers (p < 0.01), compared to women homozygous for short CYP19(TTTA) ( n ) alleles. The CYP19(TTTA) ( 7 ) allele was associated with higher serum FSH levels (p < 0.003), with lower total follicle (p < 0.02) and large follicle numbers (p < 0.03), while CYP19(TTTA) ( 7 ) allele-carriers presented more frequently with small follicles than CYP19(TTTA) ( 7 ) allele-non carriers (p < 0.01). CONCLUSIONS: CYP19 genetic variants were associated with ovarian reserve and response to standard gonadotrophin stimulation of women undergoing in vitro fertilization. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1007/s10815-011-9673-y | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/22089263 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/8020568gg6j254w1/fulltext.pdf | - |
| heal.journalName | J Assist Reprod Genet | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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