The 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral cancer

Απλή σελίδα τεκμηρίου
dc.contributor.authorVairaktaris, E.en
dc.contributor.authorYapijakis, C.en
dc.contributor.authorNkenke, E.en
dc.contributor.authorVassiliou, S.en
dc.contributor.authorVylliotis, A.en
dc.contributor.authorNixon, A. M.en
dc.contributor.authorDerka, S.en
dc.contributor.authorRagos, V.en
dc.contributor.authorSpyridonidou, S.en
dc.contributor.authorTsigris, C.en
dc.contributor.authorNeukam, F. W.en
dc.contributor.authorPatsouris, E.en
dc.date.accessioned2015-11-24T19:42:38Z
dc.date.available2015-11-24T19:42:38Z
dc.identifier.issn0361-8609-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24670
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCarboxypeptidase U/*geneticsen
dc.subjectCarcinoma, Squamous Cell/*geneticsen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectGermanyen
dc.subjectGreeceen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMouth Neoplasms/*geneticsen
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.titleThe 1040C/T polymorphism influencing thermal stability and activity of thrombin activatable fibrinolysis inhibitor is associated with risk for oral canceren
heal.abstractNo studies thus far have investigated the contribution of thrombin activatable fibrinolysis inhibitor (TAFI) to oral oncogenesis. We studied the activity-related 1040C/T polymorphism in 150 patients with oral cancer and 138 healthy controls matched by age, gender, and ethnicity. The increased-activity T allele frequency was significantly reduced in patients compared with controls (28.7% vs. 37.0%, P < 0.05). T/T homozygotes had about half the probability of developing oral cancer (O.R. 0.39, 95%C.I. 0.13-1.14), while no significant difference was observed in C/T heterozygotes. The observed prophylactic effect of increased TAFI activity might result from reduction of plasmin and inhibition of extracellular matrix dissolution.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/ajh.20985-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17636471-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/ajh.20985/asset/20985_ftp.pdf?v=1&t=h0atvxln&s=71caa113aec971d022dddc814abf1874ce031163-
heal.journalNameAm J Hematolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ