Prognostic relevance of the intrinsic growth deceleration of the first passage xenografts of human renal cell carcinomas
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bassukas, I. D.
Hofmockel, G.
Tsatalpas, P.
Eberle, V.
Maurer-Schultze, B.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Although successful xenotransplantation of human tumors in nude mice highly predicts prognosis, little is known regarding the biologic background of this correlation. In this study, the relationship between the macroscopic growth pattern of first-generation xenografts of human renal cell carcinomas in nude mice and prognosis was studied. METHODS: Macroscopic growth patterns of the first-generation xenografts of locally confined renal cell carcinomas were analyzed according to the best-fit Gompertz recursion formulas. RESULTS: The parameter "b" of the growth pattern, the measure of the intensity of growth deceleration as a function of tumor growth, strongly predicted prognosis after nephrectomy as a single factor; faster growth deceleration, i.e., lower b values, predicted better prognosis (mean follow-up, 5.2 years; P = 0.000008 for the disease free period and P = 0.000018 for overall survival). It is also the most significant single prognostic parameter among others (including staging and grading) according to a multivariate analysis. CONCLUSIONS: The parameter expressing the Gompertzian macroscopic growth deceleration of the first-generation xenografts of clinically locally confined renal cell carcinomas in nude mice explains the strong prognostic impact of xenotransplantation.
Περιγραφή
Λέξεις-κλειδιά
Animals, Carcinoma, Renal Cell/*pathology, Cell Division, Follow-Up Studies, Humans, Kidney Neoplasms/*pathology, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Transplantation, Prognosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8918411
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1097-0142(19961115)78:10<2170::AID-CNCR19>3.0.CO;2-W/asset/19_ftp.pdf?v=1&t=h0oyp0j8&s=0b54b05f583fbcf49da20819e9037b33987ddc28
http://onlinelibrary.wiley.com/store/10.1002/(SICI)1097-0142(19961115)78:10<2170::AID-CNCR19>3.0.CO;2-W/asset/19_ftp.pdf?v=1&t=h0oyp0j8&s=0b54b05f583fbcf49da20819e9037b33987ddc28
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής