Interaction between the polymorphisms of the renin-angiotensin system in preeclampsia
Φόρτωση...
Ημερομηνία
Συγγραφείς
Bouba, I.
Makrydimas, G.
Kalaitzidis, R.
Lolis, D. E.
Siamopoulos, K. C.
Georgiou, I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Obstet Gynecol Reprod Biol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Preeclampsia is considered to be a multifactorial and multisystemic disorder with a genetic predisposition. Alterations in the renin-angiotensin system are considered to play a significant role in the pathogenesis of the disease. In order to investigate the possible association of the three most common polymorphisms of the renin-angiotensin system genes with preeclampsia we have examined 41 women with preeclampsia and 102 normotensive pregnant women. DNA samples were genotyped for the M235T polymorphism of the angiotensinogen gene (AGT), the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene (ACE) and the A1166C polymorphism of the angiotensin II type 1 receptor gene (AT1R) by PCR. Allele and genotype frequencies of the AGT gene polymorphism differed between the two study groups. The TT genotype of the M235T polymorphism was significantly increased in women who developed preeclampsia (P<0.02). In addition, women with preeclampsia and TT genotype had more frequently the DD genotype or the 1166C allele than the control group showing a significant interaction between the genes. In conclusion, we found an association between the angiotensinogen variant 235T and preeclampsia as well as an interaction between the variant 235T and the two other genes studied.
Περιγραφή
Λέξεις-κλειδιά
Alleles, Angiotensinogen/genetics, Female, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A/genetics, Polymerase Chain Reaction, *Polymorphism, Genetic, Pre-Eclampsia/*genetics, Pregnancy, Receptor, Angiotensin, Type 1/genetics, Renin-Angiotensin System/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/12932862
http://ac.els-cdn.com/S0301211503000460/1-s2.0-S0301211503000460-main.pdf?_tid=5caed7ead3cfd8d485168bfbcb28dc8b&acdnat=1333614920_4224735d3ff2eb5ea7522e4e099237a7
http://ac.els-cdn.com/S0301211503000460/1-s2.0-S0301211503000460-main.pdf?_tid=5caed7ead3cfd8d485168bfbcb28dc8b&acdnat=1333614920_4224735d3ff2eb5ea7522e4e099237a7
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής